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Literature DB >> 9578637

Stretching exercises--flexibility in dihydrofolate reductase catalysis.

Abstract

As an enzyme, dihydrofolate reductase performs two tasks: transformation of its substrate dihydrofolate or folate to tetrahydrofolate, using NADPH as a cofactor, and regeneration of the enzyme for a subsequent round of catalysis. Studies discussed in this review highlight the role of conformational flexibility in both of these enzymatic functions.

Entities: Chemical Gene

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Year: 1998 PMID： 9578637 DOI： 10.1016/s1074-5521(98)90616-0

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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Cited

29 in total

1. A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors.

Authors: O A Santos-Filho; A J Hopfinger
Journal: J Comput Aided Mol Des Date: 2001-01 Impact factor: 3.686

2. One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.

Authors: E E Howell; U Shukla; S N Hicks; R D Smiley; L A Kuhn; M I Zavodszky
Journal: J Comput Aided Mol Des Date: 2001-11 Impact factor: 3.686

3. Changes in structure and dynamics of the Fv fragment of a catalytic antibody upon binding of inhibitor.

Authors: Gerard J A Kroon; Huaping Mo; Maria A Martinez-Yamout; H Jane Dyson; Peter E Wright
Journal: Protein Sci Date: 2003-07 Impact factor: 6.725

4. Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.

Authors: Argyrides Argyrou; Lianji Jin; Linda Siconilfi-Baez; Ruth H Angeletti; John S Blanchard
Journal: Biochemistry Date: 2006-11-28 Impact factor: 3.162

5. Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase.

Authors: Kim F Wong; Tzvia Selzer; Stephen J Benkovic; Sharon Hammes-Schiffer
Journal: Proc Natl Acad Sci U S A Date: 2005-04-05 Impact factor: 11.205

6. The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase.

Authors: Lin Wang; Nina M Goodey; Stephen J Benkovic; Amnon Kohen
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2006-08-29 Impact factor: 6.237

Stretching exercises--flexibility in dihydrofolate reductase catalysis.

1. A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors.

2. One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.

3. Changes in structure and dynamics of the Fv fragment of a catalytic antibody upon binding of inhibitor.

4. Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.

5. Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase.

6. The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase.

7. Effects of a distal mutation on active site chemistry.

8. Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase.

9. Computational approach for ranking mutant enzymes according to catalytic reaction rates.

Review 10. Relationship of femtosecond-picosecond dynamics to enzyme-catalyzed H-transfer.