OBJECTIVE: To compare self-reports of immune-related diseases in diethylstilbestrol (DES) daughters and controls. Prenatal exposure to DES has been associated with several malformations in the lower genital tract, a higher prevalence of adenosis, and increased risk of clear cell adenocarcinoma, and estrogen-dependent tumors. Lately, reports have been published indicating a link between DES exposure and alterations in the immune system. The present study focuses on the possible clinical consequences of an affected immune system. STUDY DESIGN: DES daughters (n=170) and control women (n=123) completed questionnaires containing lists of immune-related diseases, specified into three categories (i) allergies, (ii) auto-immune disorders, and (iii) infectious diseases. RESULTS: DES daughters reported significantly more disease conditions than the controls. Analyses for separate disease categories (allergies, auto-immune disorders, infectious disease), yielded a statistically significant difference only for infectious disease. Within this last category, two infectious diseases yielded highly significant differences: bladder infection and measles. CONCLUSION: The present findings suggest that DES daughters are at higher risk of developing immune-related disease states.
OBJECTIVE: To compare self-reports of immune-related diseases in diethylstilbestrol (DES) daughters and controls. Prenatal exposure to DES has been associated with several malformations in the lower genital tract, a higher prevalence of adenosis, and increased risk of clear cell adenocarcinoma, and estrogen-dependent tumors. Lately, reports have been published indicating a link between DES exposure and alterations in the immune system. The present study focuses on the possible clinical consequences of an affected immune system. STUDY DESIGN:DES daughters (n=170) and control women (n=123) completed questionnaires containing lists of immune-related diseases, specified into three categories (i) allergies, (ii) auto-immune disorders, and (iii) infectious diseases. RESULTS:DES daughters reported significantly more disease conditions than the controls. Analyses for separate disease categories (allergies, auto-immune disorders, infectious disease), yielded a statistically significant difference only for infectious disease. Within this last category, two infectious diseases yielded highly significant differences: bladder infection and measles. CONCLUSION: The present findings suggest that DES daughters are at higher risk of developing immune-related disease states.
Authors: Ronald N Hines; Dana Sargent; Herman Autrup; Linda S Birnbaum; Robert L Brent; Nancy G Doerrer; Elaine A Cohen Hubal; Daland R Juberg; Christian Laurent; Robert Luebke; Klaus Olejniczak; Christopher J Portier; William Slikker Journal: Toxicol Sci Date: 2009-09-21 Impact factor: 4.849
Authors: William C Strohsnitter; Kenneth L Noller; Rebecca Troisi; Stanley J Robboy; Elizabeth E Hatch; Linda Titus-Ernstoff; Raymond H Kaufman; Julie R Palmer; Diane Anderson; Robert N Hoover Journal: J Rheumatol Date: 2010-07-15 Impact factor: 4.666
Authors: G R Cunha; J G Forsberg; R Golden; A Haney; T Iguchi; R Newbold; S Swan; W Welshons Journal: Environ Health Perspect Date: 1999-08 Impact factor: 9.031