BACKGROUND: Secretory immunity is a major defence mechanism against infections at mucosal surfaces which are common in HIV infected patients. AIMS: To analyse intestinal immunoglobulin production in HIV infection in comparison with that in saliva and serum. PATIENTS AND METHODS: Immunoglobulin G (IgG), A (IgA), and M (IgM) concentrations were determined in supernatants of short term cultured duodenal biopsy samples, serum, and saliva from HIV infected patients (n = 28) and controls (n = 14) by radial immunodiffusion. RESULTS: IgG was increased in the supernatants of short term cultured biopsy samples and saliva from HIV infected patients compared with controls (p < 0.01), but IgA and IgM levels were normal. In contrast, both IgG and IgA concentrations in serum were higher in HIV infected patients than in controls (p < 0.002). No correlation was found between IgA produced by duodenal biopsy specimens and serum IgA. CONCLUSION: Abnormalities in mucosal immunoglobulin production in HIV infection were surprisingly small, indicating that specific secretory immunity rather than quantitative immunoglobulin production may be impaired. However, increased production of IgG could contribute to mucosal inflammation by complement activation. Our findings of normal mucosal IgA production and the lack of correlation between serum and mucosal IgA argues against an intestinal origin for the increased serum IgA levels in HIV infected patients.
BACKGROUND: Secretory immunity is a major defence mechanism against infections at mucosal surfaces which are common in HIV infectedpatients. AIMS: To analyse intestinal immunoglobulin production in HIV infection in comparison with that in saliva and serum. PATIENTS AND METHODS: Immunoglobulin G (IgG), A (IgA), and M (IgM) concentrations were determined in supernatants of short term cultured duodenal biopsy samples, serum, and saliva from HIV infectedpatients (n = 28) and controls (n = 14) by radial immunodiffusion. RESULTS: IgG was increased in the supernatants of short term cultured biopsy samples and saliva from HIV infectedpatients compared with controls (p < 0.01), but IgA and IgM levels were normal. In contrast, both IgG and IgA concentrations in serum were higher in HIV infectedpatients than in controls (p < 0.002). No correlation was found between IgA produced by duodenal biopsy specimens and serum IgA. CONCLUSION: Abnormalities in mucosal immunoglobulin production in HIV infection were surprisingly small, indicating that specific secretory immunity rather than quantitative immunoglobulin production may be impaired. However, increased production of IgG could contribute to mucosal inflammation by complement activation. Our findings of normal mucosal IgA production and the lack of correlation between serum and mucosal IgA argues against an intestinal origin for the increased serum IgA levels in HIV infectedpatients.
Authors: J E Crabtree; J D Taylor; J I Wyatt; R V Heatley; T M Shallcross; D S Tompkins; B J Rathbone Journal: Lancet Date: 1991-08-10 Impact factor: 79.321
Authors: H-J Epple; J Friebel; V Moos; H Troeger; S M Krug; K Allers; K Schinnerling; A Fromm; B Siegmund; M Fromm; J D Schulzke; T Schneider Journal: Mucosal Immunol Date: 2017-02-08 Impact factor: 7.313
Authors: R Bücker; S M Krug; V Moos; C Bojarski; M R Schweiger; M Kerick; A Fromm; S Janßen; M Fromm; N A Hering; B Siegmund; T Schneider; C Barmeyer; J D Schulzke Journal: Mucosal Immunol Date: 2017-08-02 Impact factor: 7.313
Authors: Clarisa M Buckner; Susan Moir; Lela Kardava; Jason Ho; Brian H Santich; Leo Jin Young Kim; Emily K Funk; Amy K Nelson; Britanny Winckler; Cheryl L Chairez; Narda L Theobald-Whiting; Sandra Anaya-O'Brien; Meghna Alimchandani; Martha M Quezado; Michael D Yao; Joseph A Kovacs; Tae-Wook Chun; Anthony S Fauci; Harry L Malech; Suk See De Ravin Journal: J Allergy Clin Immunol Date: 2013-12-25 Impact factor: 10.793
Authors: T Aebischer; D Bumann; H J Epple; W Metzger; T Schneider; G Cherepnev; A K Walduck; D Kunkel; V Moos; C Loddenkemper; I Jiadze; M Panasyuk; M Stolte; D Y Graham; M Zeitz; T F Meyer Journal: Gut Date: 2008-04-16 Impact factor: 23.059