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Literature DB >> 9577284

Reduced expression of C5a receptors on neutrophils from cord blood.

Abstract

AIM: To describe further functional deficiencies of neonatal neutrophils by measuring the expression of C5a receptors.
METHODS: C5a uptake was measured using flow cytometry with fluorescein isothiocynate labelled recombinant C5a. The response of neutrophils to stimulation with C5a and fMLP was tested by measuring migration and exocytosis of myeloperoxidase and lactoferrin.
RESULTS: C5a mean fluorescence on neutrophils from neonates was significantly lower (22.4 (SD 3.5)) than in adult controls (31.5 (3.1)). Neutrophils from neonates migrated poorly towards both C5a and fMLP compared with those from adult controls. Exocytosis of myeloperoxidase, but not lactoferrin from neonatal neutrophils stimulated with C5a, was significantly lower than in adult controls. fMLP stimulation, on the other hand, resulted in significantly higher exocytosis in neonates.
CONCLUSION: The lower expression of C5a receptors on neutrophils from neonates could be related to reduced C5a mediated exocytosis of myeloperoxidase.

Entities: Chemical Disease Gene

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Year: 1998 PMID： 9577284 PMCID： PMC1720753 DOI： 10.1136/fn.78.2.f129

Source DB: PubMed Journal: Arch Dis Child Fetal Neonatal Ed ISSN： 1359-2998 Impact factor: 5.747

38 in total

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Authors: K Yasui; M Masuda; T Tsuno; T Matsuoka; A Komiyama; T Akabane; K Murata
Journal: Clin Exp Immunol Date: 1990-07 Impact factor: 4.330

2. The role of formylpeptide receptors, C5a receptors, and cytosolic-free calcium in neutrophil priming.

Authors: W Zimmerli; A M Reber; C A Dahinden
Journal: J Infect Dis Date: 1990-02 Impact factor: 5.226

Review 3. Complement deficiency and neutrophil dysfunction as risk factors for bacterial infection in newborns and the role of granulocyte transfusion in therapy.

Authors: M Berger
Journal: Rev Infect Dis Date: 1990 May-Jun

4. Deficient total cell content of CR3 (CD11b) in neonatal neutrophils.

Authors: N Abughali; M Berger; M F Tosi
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5. Improved chemotactic ability of neonatal polymorphonuclear cells induced by mild membrane rigidification.

Authors: B Wolach; M Ben Dor; O Chomsky; R Gavrieli; M Shinitzky
Journal: J Leukoc Biol Date: 1992-04 Impact factor: 4.962

6. Diversity in regulation of adhesion molecules (Mac-1 and L-selectin) in monocytes and neutrophils from neonates and adults.

Authors: C Török; J Lundahl; J Hed; H Lagercrantz
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7. Subcellular localization and translocation of the receptor for N-formylmethionyl-leucyl-phenylalanine in human neutrophils.

Authors: H Sengeløv; F Boulay; L Kjeldsen; N Borregaard
Journal: Biochem J Date: 1994-04-15 Impact factor: 3.857

8. An enzyme-linked immunosorbent assay for plasma-lactoferrin. Concentrations in 362 healthy, adult blood donors.

Authors: S Antonsen; P Wiggers; J Dalhøj; O Blaabjerg
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9. Regulation of C5a and formyl peptide receptor expression on human polymorphonuclear leukocytes.

Authors: D E Van Epps; S Simpson; J G Bender; D E Chenoweth
Journal: J Immunol Date: 1990-02-01 Impact factor: 5.422

10. Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils.

Authors: H Sengeløv; L Kjeldsen; M S Diamond; T A Springer; N Borregaard
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