OBJECTIVE: Determination of the effects of hormonal replacement therapy (HRT) on various ocular parameters and symptoms in postmenopausal women. DESIGN: Prospective study. SETTING: Department of Obstetrics and Gynecology, University "Federico II" of Naples. PATIENTS: 14 healthy women treated orally with equine conjugated estrogen in continuous (0,625 mg/daily) and acetate-medroxyprogesteron (10 mg/daily) from 17th to 28th day for three months. MEASURES: Ocular symptomatology, intraocular pressure (IOP), lacrimal secretion, reflected and basal and corneal thickness. RESULTS: After 3 months of HRT the IOP was reduced of 10.8% (p < 0.005), the lacrimal secretion, reflected and basal, increased of 19% and 48%, respectively and the corneal thickness increased of 16.6%. CONCLUSION: The HRT has a positive effect on ocular physiology.
OBJECTIVE: Determination of the effects of hormonal replacement therapy (HRT) on various ocular parameters and symptoms in postmenopausal women. DESIGN: Prospective study. SETTING: Department of Obstetrics and Gynecology, University "Federico II" of Naples. PATIENTS: 14 healthy women treated orally with equine conjugated estrogen in continuous (0,625 mg/daily) and acetate-medroxyprogesteron (10 mg/daily) from 17th to 28th day for three months. MEASURES: Ocular symptomatology, intraocular pressure (IOP), lacrimal secretion, reflected and basal and corneal thickness. RESULTS: After 3 months of HRT the IOP was reduced of 10.8% (p < 0.005), the lacrimal secretion, reflected and basal, increased of 19% and 48%, respectively and the corneal thickness increased of 16.6%. CONCLUSION: The HRT has a positive effect on ocular physiology.
Authors: Janey L Wiggs; Jae Hee Kang; Brian L Yaspan; Daniel B Mirel; Cathy Laurie; Andrew Crenshaw; Wendy Brodeur; Stephanie Gogarten; Lana M Olson; Wael Abdrabou; Elizabeth DelBono; Stephanie Loomis; Jonathan L Haines; Louis R Pasquale Journal: Hum Mol Genet Date: 2011-08-26 Impact factor: 6.150
Authors: Jae Hee Kang; Janey L Wiggs; Bernard A Rosner; Susan E Hankinson; Wael Abdrabou; Bao Jian Fan; Jonathan Haines; Louis R Pasquale Journal: Invest Ophthalmol Vis Sci Date: 2009-10-08 Impact factor: 4.799
Authors: Louis R Pasquale; Stephanie J Loomis; Robert N Weinreb; Jae H Kang; Brian L Yaspan; Jessica Cooke Bailey; Douglas Gaasterland; Terry Gaasterland; Richard K Lee; William K Scott; Paul R Lichter; Donald L Budenz; Yutao Liu; Tony Realini; David S Friedman; Catherine A McCarty; Sayoko E Moroi; Lana Olson; Joel S Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J Zack; Murray Brilliant; Arthur J Sit; William G Christen; John Fingert; Peter Kraft; Kang Zhang; R Rand Allingham; Margaret A Pericak-Vance; Julia E Richards; Michael A Hauser; Jonathan L Haines; Janey L Wiggs Journal: Mol Vis Date: 2013-07-12 Impact factor: 2.367