Literature DB >> 9573184

Control of 5',5'-dinucleoside triphosphate catabolism by APH1, a Saccharomyces cerevisiae analog of human FHIT.

J Chen1, A Brevet, S Blanquet, P Plateau.   

Abstract

The putative human tumor suppressor gene FHIT (fragile histidine triad) (M. Ohta et al., Cell 84:587-597, 1996) encodes a protein behaving in vitro as a dinucleoside 5',5"'-P1,P3-triphosphate (Ap3A) hydrolase. In this report, we show that the Saccharomyces cerevisiae APH1 gene product, which resembles human Fhit protein, also hydrolyzes dinucleoside 5',5'-polyphosphates, with Ap3A being the preferred substrate. Accordingly, disruption of the APH1 gene produced viable S. cerevisiae cells containing reduced Ap3A-hydrolyzing activity and a 30-fold-elevated Ap3N concentration.

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Year:  1998        PMID： 9573184      PMCID： PMC107174          DOI： 10.1128/JB.180.9.2345-2349.1998

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  35 in total

1.  Design and characterization of Escherichia coli mutants devoid of Ap4N-hydrolase activity.

Authors:  F Lévĕque; S Blanchin-Roland; G Fayat; P Plateau; S Blanquet
Journal:  J Mol Biol       Date:  1990-03-20       Impact factor: 5.469

2.  Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase.

Authors:  P Plateau; M Fromant; J M Schmitter; J M Buhler; S Blanquet
Journal:  J Bacteriol       Date:  1989-12       Impact factor: 3.490

3.  Catabolism of bis(5'-nucleosidyl) oligophosphates in Escherichia coli: metal requirements and substrate specificity of homogeneous diadenosine-5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase.

Authors:  P Plateau; M Fromant; A Brevet; A Gesquière; S Blanquet
Journal:  Biochemistry       Date:  1985-02-12       Impact factor: 3.162

4.  Genetic engineering of methionyl-tRNA synthetase: in vitro regeneration of an active synthetase by proteolytic cleavage of a methionyl-tRNA synthetase--beta-galactosidase chimeric protein.

Authors:  P H Hirel; F Lévêque; P Mellot; F Dardel; M Panvert; Y Mechulam; G Fayat
Journal:  Biochimie       Date:  1988-06       Impact factor: 4.079

5.  MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family.

Authors:  C D Lima; K L D'Amico; I Naday; G Rosenbaum; E M Westbrook; W A Hendrickson
Journal:  Structure       Date:  1997-06-15       Impact factor: 5.006

6.  Variation of Ap4A and other dinucleoside polyphosphates in stressed Drosophila cells.

Authors:  A Brevet; P Plateau; M Best-Belpomme; S Blanquet
Journal:  J Biol Chem       Date:  1985-12-15       Impact factor: 5.157

7.  Non-adenylylated bis(5'-nucleosidyl) tetraphosphates occur in Saccharomyces cerevisiae and in Escherichia coli and accumulate upon temperature shift or exposure to cadmium.

Authors:  H Coste; A Brevet; P Plateau; S Blanquet
Journal:  J Biol Chem       Date:  1987-09-05       Impact factor: 5.157

8.  RPC40, a unique gene for a subunit shared between yeast RNA polymerases A and C.

Authors:  C Mann; J M Buhler; I Treich; A Sentenac
Journal:  Cell       Date:  1987-02-27       Impact factor: 41.582

9.  Transformation of intact yeast cells treated with alkali cations.

Authors:  H Ito; Y Fukuda; K Murata; A Kimura
Journal:  J Bacteriol       Date:  1983-01       Impact factor: 3.490

10.  A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

Authors:  R S Sikorski; P Hieter
Journal:  Genetics       Date:  1989-05       Impact factor: 4.562
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  7 in total

1.  Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.

Authors:  Charles Brenner
Journal:  Biochemistry       Date:  2002-07-23       Impact factor: 3.162

Review 2.  The histidine triad superfamily of nucleotide-binding proteins.

Authors:  C Brenner; P Bieganowski; H C Pace; K Huebner
Journal:  J Cell Physiol       Date:  1999-11       Impact factor: 6.384

3.  Disruption and overexpression of the Schizosaccharomyces pombe aph1 gene and the effects on intracellular diadenosine 5',5'''-P1, P4-tetraphosphate (Ap4A), ATP and ADP concentrations.

Authors:  S W Ingram; L D Barnes
Journal:  Biochem J       Date:  2000-09-15       Impact factor: 3.857

4.  The histidine triad protein Hint is not required for murine development or Cdk7 function.

Authors:  Nina Korsisaari; Derrick J Rossi; Keijo Luukko; Kay Huebner; Mark Henkemeyer; Tomi P Mäkelä
Journal:  Mol Cell Biol       Date:  2003-06       Impact factor: 4.272

5.  Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae.

Authors:  Marta Rubio-Texeira; James M Varnum; Pawel Bieganowski; Charles Brenner
Journal:  BMC Mol Biol       Date:  2002-05-20       Impact factor: 2.946

6.  Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS.

Authors:  Valerio Taverniti; Bertrand Séraphin
Journal:  Nucleic Acids Res       Date:  2014-11-28       Impact factor: 16.971

7.  The fission yeast FHIT homolog affects checkpoint control of proliferation and is regulated by mitochondrial electron transport.

Authors:  Johanna J Sjölander; Per Sunnerhagen
Journal:  Cell Biol Int       Date:  2019-10-02       Impact factor: 3.612
  7 in total

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