Literature DB >> 9572737

Chaos, persistence, and evolution of strain structure in antigenically diverse infectious agents.

S Gupta1, N Ferguson, R Anderson.   

Abstract

The effects of selection by host immune responses on transmission dynamics was analyzed in a broad class of antigenically diverse pathogens. Strong selection can cause pathogen populations to stably segregate into discrete strains with nonoverlapping antigenic repertoires. However, over a wide range of intermediate levels of selection, strain structure is unstable, varying in a manner that is either cyclical or chaotic. These results have implications for the interpretation of longitudinal epidemiological data on strain or serotype abundance, design of surveillance strategies, and the assessment of multivalent vaccine trials.

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Year:  1998        PMID： 9572737     DOI： 10.1126/science.280.5365.912

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  119 in total

1.  Transmission dynamics and epidemiology of dengue: insights from age-stratified sero-prevalence surveys.

Authors:  N M Ferguson; C A Donnelly; R M Anderson
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-04-29       Impact factor: 6.237

2.  The effects of host heterogeneity on pathogen population structure.

Authors:  S Gupta; A Galvani
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-04-29       Impact factor: 6.237

3.  Etiology of interepidemic periods of mosquito-borne disease.

Authors:  S I Hay; M F Myers; D S Burke; D W Vaughn; T Endy; N Ananda; G D Shanks; R W Snow; D J Rogers
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

Review 4.  Role of genomic typing in taxonomy, evolutionary genetics, and microbial epidemiology.

Authors:  A van Belkum; M Struelens; A de Visser; H Verbrugh; M Tibayrenc
Journal:  Clin Microbiol Rev       Date:  2001-07       Impact factor: 26.132

5.  On the determinants of population structure in antigenically diverse pathogens.

Authors:  M Gabriela M Gomes; Graham F Medley; D James Nokes
Journal:  Proc Biol Sci       Date:  2002-02-07       Impact factor: 5.349

6.  Dynamics and selection of many-strain pathogens.

Authors:  Julia R Gog; Bryan T Grenfell
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-12       Impact factor: 11.205

7.  The effects of host contact network structure on pathogen diversity and strain structure.

Authors:  Caroline O'F Buckee; Katia Koelle; Matthew J Mustard; Sunetra Gupta
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-09       Impact factor: 11.205

8.  Structural identifiability analysis of some highly structured families of statespace models using differential algebra.

Authors:  Gabriella Margaria; Eva Riccomagno; Lisa J White
Journal:  J Math Biol       Date:  2004-03-03       Impact factor: 2.259

9.  Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions.

Authors:  Virginia E Pitzer; Manish M Patel; Ben A Lopman; Cécile Viboud; Umesh D Parashar; Bryan T Grenfell
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-14       Impact factor: 11.205

10.  Increased frequency of travel in the presence of cross-immunity may act to decrease the chance of a global pandemic.

Authors:  R N Thompson; C P Thompson; O Pelerman; S Gupta; U Obolski
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2019-06-24       Impact factor: 6.237
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