Literature DB >> 9570510

Tat, Tat-associated kinase, and transcription.

K T Jeang1.   

Abstract

The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb.

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Year:  1998        PMID： 9570510     DOI： 10.1007/BF02253352

Source DB:  PubMed          Journal:  J Biomed Sci        ISSN： 1021-7770            Impact factor:   8.410


  9 in total

Review 1.  Regulation of HIV-1 transcription.

Authors:  K A Roebuck; M Saifuddin
Journal:  Gene Expr       Date:  1999

2.  Jembrana disease virus Tat can regulate human immunodeficiency virus (HIV) long terminal repeat-directed gene expression and can substitute for HIV Tat in viral replication.

Authors:  H Chen; J He; S Fong; G Wilcox; C Wood
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

3.  An intact TAR element and cytoplasmic localization are necessary for efficient packaging of human immunodeficiency virus type 1 genomic RNA.

Authors:  C Helga-Maria; M L Hammarskjöld; D Rekosh
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

4.  A second-site mutation that restores replication of a Tat-defective human immunodeficiency virus.

Authors:  K Verhoef; B Berkhout
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

5.  HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription.

Authors:  Sergei Nekhai; Meisheng Zhou; Anne Fernandez; William S Lane; Ned J C Lamb; John Brady; Ajit Kumar
Journal:  Biochem J       Date:  2002-06-15       Impact factor: 3.857

6.  The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter.

Authors:  Sandra Kao; Eri Miyagi; Rosa Mallorson; Hideki Saito; Sayaka Sukegawa; Abhik Mukherji; Allyson Mateja; Damien Ferhadian; Helena Fabryova; Kathleen Clouse; Klaus Strebel
Journal:  J Virol       Date:  2022-06-29       Impact factor: 6.549

7.  Evolution of the human immunodeficiency virus type 1 long terminal repeat promoter by conversion of an NF-kappaB enhancer element into a GABP binding site.

Authors:  K Verhoef; R W Sanders; V Fontaine; S Kitajima; B Berkhout
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

8.  Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription.

Authors:  Christian Boudier; Nicolas Humbert; Françoise Chaminade; Yingying Chen; Hugues de Rocquigny; Julien Godet; Olivier Mauffret; Philippe Fossé; Yves Mély
Journal:  Nucleic Acids Res       Date:  2013-10-22       Impact factor: 16.971

9.  A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes.

Authors:  Lina Rustanti; Hongping Jin; Mary Lor; Min Hsuan Lin; Daniel J Rawle; David Harrich
Journal:  Virol J       Date:  2017-03-14       Impact factor: 4.099
  9 in total

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