Literature DB >> 9570462

Muscarinic receptor subtypes in the rat prostate gland.

W A Lau1, J N Pennefather.   

Abstract

Muscarinic receptor subtypes mediating carbachol-induced contractions of the rat prostatic smooth muscle were determined. The rank order of potency of muscarinic receptor antagonists in blocking the effects of carbachol was (mean pKB estimates in parentheses): atropine (8.90) >> para-fluorohexahydrosiladifenidol (7.75) > or = hexahydrosiladifenidol (7.62) > methoctramine (6.89) > or = pirenzepine (6.68) > or = himbacine (6.67). The specific binding of [3H]quinuclidinyl benzilate to the rat prostatic homogenates was competitively inhibited by (mean pKi values in parentheses): atropine (8.89) >> hexahydrosiladifenidol (7.86) > para-fluorohexahydrosiladifenidol (7.28) > or = himbacine (7.22) > pirenzepine (6.63) > or = methoctramine (6.38). These profiles, whilst different, indicate the probable involvement of muscarinic M3 receptors in the carbachol-induced contraction.

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Year:  1998        PMID： 9570462     DOI： 10.1016/s0014-2999(97)01535-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  The residual nonadrenergic contractile response to nerve stimulation of the mouse prostate is mediated by acetylcholine but not ATP in a comparison with the mouse vas deferens.

Authors:  Carl W White; Jennifer L Short; John M Haynes; Richard J Evans; Sabatino Ventura
Journal:  J Pharmacol Exp Ther       Date:  2010-08-19       Impact factor: 4.030

Review 2.  Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH).

Authors:  S Ventura; V l Oliver; C W White; J H Xie; J M Haynes; B Exintaris
Journal:  Br J Pharmacol       Date:  2011-07       Impact factor: 8.739

3.  Cholinergic facilitation of neurotransmission to the smooth muscle of the guinea-pig prostate gland.

Authors:  W A Lau; J N Pennefather; F J Mitchelson
Journal:  Br J Pharmacol       Date:  2000-07       Impact factor: 8.739

4.  Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype.

Authors:  M Matsui; D Motomura; H Karasawa; T Fujikawa; J Jiang; Y Komiya; S Takahashi; M M Taketo
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-15       Impact factor: 11.205

5.  M3 subtype of muscarinic receptors mediate Ca2+ release from intracellular stores in rat prostate neuroendocrine cells.

Authors:  Jin Kyoung Kim; Soo Jung Kim; Ji Eun Lee; Kyeong Min Min; Sung Joon Kim
Journal:  J Korean Med Sci       Date:  2005-04       Impact factor: 2.153

Review 6.  Muscarinic acetylcholine receptor subtypes in the male reproductive tract: expression and function in rat efferent ductules and epididymis.

Authors:  Maria Christina W Avellar; Erica R Siu; Fabiana Yasuhara; Elisabeth Maróstica; Catarina S Porto
Journal:  J Mol Neurosci       Date:  2009-08-20       Impact factor: 3.444

7.  Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 receptor single knockout mice.

Authors:  Yoshihiko Ito; Luvsandorj Oyunzul; Masanao Seki; Tomomi Fujino Oki; Minoru Matsui; Shizuo Yamada
Journal:  Br J Pharmacol       Date:  2009-04       Impact factor: 8.739

8.  Correlation between Cholinergic Innervation, Autophagy, and Etiopathology of Benign Prostatic Hyperplasia.

Authors:  Jian-Liang Cai; Wei-Min Yao; Yan-Qun Na
Journal:  Chin Med J (Engl)       Date:  2017-08-20       Impact factor: 2.628
  8 in total

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