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Literature DB >> 9569208

Expression of the factor VII activating protease, hepsin, in situ in renal cell carcinoma.

L R Zacharski, D L Ornstein, V A Memoli, S M Rousseau, W Kisiel.

Abstract

Entities: Disease Gene

Mesh：

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Year: 1998 PMID： 9569208

Source DB: PubMed Journal: Thromb Haemost ISSN： 0340-6245 Impact factor: 5.249

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7 in total

1. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.

Authors: Sylvia Herter; Derek E Piper; Wade Aaron; Timothy Gabriele; Gene Cutler; Ping Cao; Ami S Bhatt; Youngchool Choe; Charles S Craik; Nigel Walker; David Meininger; Timothy Hoey; Richard J Austin
Journal: Biochem J Date: 2005-08-15 Impact factor: 3.857

2. Phenotypic analysis of mice lacking the Tmprss2-encoded protease.

Authors: Tom S Kim; Cynthia Heinlein; Robert C Hackman; Peter S Nelson
Journal: Mol Cell Biol Date: 2006-02 Impact factor: 4.272

3. Identification and characterization of small-molecule inhibitors of hepsin.

Authors: John R Chevillet; Gemma J Park; Antonio Bedalov; Julian A Simon; Valeri I Vasioukhin
Journal: Mol Cancer Ther Date: 2008-10 Impact factor: 6.261

4. Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues.

Authors: John D Hooper; Luisa Campagnolo; Goodarz Goodarzi; Tony N Truong; Heidi Stuhlmann; James P Quigley
Journal: Biochem J Date: 2003-08-01 Impact factor: 3.857

Expression of the factor VII activating protease, hepsin, in situ in renal cell carcinoma.

1. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.

2. Phenotypic analysis of mice lacking the Tmprss2-encoded protease.

3. Identification and characterization of small-molecule inhibitors of hepsin.

4. Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues.

5. Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model.

6. Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival.

7. High Hepsin expression predicts poor prognosis in Gastric Cancer.