Literature DB >> 956785

Virulence heterogeneity of a predominantly avirulent Western equine encephalitis virus population.

P B Jahrling.   

Abstract

Selective removal of small plaque (SP) Western equine encephalitis (WEE) virus from a population heterogeneous with respect to virulence and plaque morphology permitted direct detection of a small sub-population of virulent large plaque (LP) WEE virus. Selective removal of SP-WEE virus was achieved by intracardiac (i.c.a.) inoculation of hamsters; plasma obtained 60 min after inoculation was proportionately enriched for LP-WEE virus since only the SP-WEE virus was cleared. By this method, the proportion of LP- to SP-WEE virus, in a population of SP-WEE virus which appeared to be homogeneous by conventional plaquing methods, was calculated to be 1 LP- to 250000 SP-WEE virions. The presence of a virulent LP-WEE virus sub-population explains why a single passage of a high but not low dose of SP-WEE virus in hamsters resulted in the emergence of an LP-WEE virus population with enhanced virulence.

Entities:  

Mesh：

Year:  1976        PMID： 956785     DOI： 10.1099/0022-1317-32-1-121

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  9 in total

1.  Large-plaque mutants of Sindbis virus show reduced binding to heparan sulfate, heightened viremia, and slower clearance from the circulation.

Authors:  A P Byrnes; D E Griffin
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model.

Authors:  Justin G Julander; Venkatraman Siddharthan; Lawrence M Blatt; Kristiina Schafer; Robert W Sidwell; John D Morrey
Journal:  Virology       Date:  2006-11-21       Impact factor: 3.616

3.  Evaluation of vascular clearance as a marker for virulence of alphaviruses: disassociation of rapid clearance with low virulence of venezuelan encephalitis virus strains in guinea pigs.

Authors:  P B Jahrling; G B Heisey; R A Hesse
Journal:  Infect Immun       Date:  1977-08       Impact factor: 3.441

4.  Early activation of the host complement system is required to restrict central nervous system invasion and limit neuropathology during Venezuelan equine encephalitis virus infection.

Authors:  Christopher B Brooke; Alexandra Schäfer; Glenn K Matsushima; Laura J White; Robert E Johnston
Journal:  J Gen Virol       Date:  2011-12-28       Impact factor: 3.891

5.  Binding of Sindbis virus to cell surface heparan sulfate.

Authors:  A P Byrnes; D E Griffin
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

6.  Chromatographic separations of alphavirus strains by hydroxylapatite.

Authors:  P B Jahrling; J L Beall
Journal:  J Clin Microbiol       Date:  1977-09       Impact factor: 5.948

7.  Correlation between virus-cell receptor properties of alphaviruses in vitro and virulence in vivo.

Authors:  S C Marker; P B Jahrling
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

8.  Radioimmunoassay for quantitation of antibodies to alphaviruses with staphylococcal protein A.

Authors:  P B Jahrling; R A Hesse; J F Metzger
Journal:  J Clin Microbiol       Date:  1978-07       Impact factor: 5.948

Review 9.  Innate immune surveillance of the circulation: A review on the removal of circulating virions from the bloodstream.

Authors:  Stephanie E Ander; Frances S Li; Kathryn S Carpentier; Thomas E Morrison
Journal:  PLoS Pathog       Date:  2022-05-05       Impact factor: 7.464
  9 in total

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