| Literature DB >> 9566412 |
M A Eldon1, B A Underwood, E J Randinitis, A J Sedman.
Abstract
Anticonvulsants that induce hepatic metabolism increase clearance of oral contraceptive hormones and thereby cause contraceptive failure. Gabapentin is not metabolized in humans and has little liability for causing metabolic-based drug-drug interactions. In healthy women receiving 2.5 mg norethindrone acetate and 50 microg ethinyl estradiol daily for three consecutive menstrual cycles, concurrent gabapentin administration did not alter the steady-state pharmacokinetics of either hormone. Thus, gabapentin is unlikely to cause contraceptive failure.Entities:
Keywords: Americas; Biology; Clinical Research; Contraception; Contraceptive Agents, Estrogen--pharmacodynamics; Contraceptive Agents, Female--pharmacodynamics; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Contraceptive Methods--pharmacodynamics; Developed Countries; Drug Interactions; Drugs; Ethinyl Estradiol--pharmacodynamics; Family Planning; Hepatic Effects; Norethindrone Acetate--pharmacodynamics; Norethindrone--pharmacodynamics; North America; Northern America; Oral Contraceptives, Combined--pharmacodynamics; Oral Contraceptives--pharmacodynamics; Physiology; Research Methodology; Research Report; Treatment; United States
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Year: 1998 PMID： 9566412 DOI： 10.1212/wnl.50.4.1146
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910