| Literature DB >> 9562462 |
P E Fraser1, G Levesque, G Yu, L R Mills, J Thirlwell, M Frantseva, S E Gandy, M Seeger, P L Carlen, P St George-Hyslop.
Abstract
The metabolic pathways governing the turnover of presenilin 1 (PS1) have been incompletely worked out. The PS1 holoprotein has low abundance in many cells and appears to undergo endoproteolytic cleavage near residue 298. We provide evidence that one mechanism by which the PS1 holoprotein is degraded is through the action of the 26S proteasome. We also show that the proteasome does not participate in the endoproteolytic cleavage.Entities:
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Year: 1998 PMID： 9562462 DOI： 10.1016/s0197-4580(98)00029-3
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673