Literature DB >> 9561844

Analysis of antigen receptor signalling using mouse gene targeting.

V L Tybulewicz1.   

Abstract

Gene targeting in mice has enabled the study of antigen receptor signalling in primary lymphocytes. Furthermore, it has provided the tools to directly assess the function of individual signalling proteins by mutation of the genes that code for them. Some of the results that gene targeting has produced have confirmed previous views of the function of particular proteins. Others have given surprising results and overturned accepted viewpoints.

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Year:  1998        PMID： 9561844     DOI： 10.1016/s0955-0674(98)80142-7

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  4 in total

1.  CD3γ/δ in sea bass (Dicentrarchus labrax): Molecular characterization and expression analysis.

Authors:  Elisa Randelli; Giuseppe Scapigliati; Francesco Buonocore
Journal:  Results Immunol       Date:  2011-08-30

2.  The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.

Authors:  J E van Leeuwen; P K Paik; L E Samelson
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

3.  CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia.

Authors:  Fatih M Uckun; Patricia Goodman; Hong Ma; Ilker Dibirdik; Sanjive Qazi
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-14       Impact factor: 11.205

4.  Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.

Authors:  Mariëlle C Haks; Elsa Pépin; Jeroen H N van den Brakel; Sigrid A A Smeele; Stanley M Belkowski; Helmut W H G Kessels; Paul Krimpenfort; Ada M Kruisbeek
Journal:  J Exp Med       Date:  2002-07-01       Impact factor: 14.307
  4 in total

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