Literature DB >> 9561843

Mads and Smads in TGF beta signalling.

L Attisano1, J L Wrana.   

Abstract

The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases.

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Year:  1998        PMID： 9561843     DOI： 10.1016/s0955-0674(98)80141-5

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  36 in total

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3.  High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells.

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4.  Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice.

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Review 5.  Targeting TGF-β signaling in cancer.

Authors:  Lior H Katz; Ying Li; Jiun-Sheng Chen; Nina M Muñoz; Avijit Majumdar; Jian Chen; Lopa Mishra
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6.  Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis.

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7.  Systematic analysis of the TGF-beta/Smad signalling pathway in the rhabdomyosarcoma cell line RD.

Authors:  Hua Wang; Guang-Hua Yang; Hong Bu; Qiao Zhou; Li-Xin Guo; Shou-Li Wang; Lv Ye
Journal:  Int J Exp Pathol       Date:  2003-06       Impact factor: 1.925

8.  TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF.

Authors:  Sang Soo Kim; Kirti Shetty; Varalakshmi Katuri; Krit Kitisin; Hye Jung Baek; Yi Tang; Blair Marshall; Lynt Johnson; Bibhuti Mishra; Lopa Mishra
Journal:  Biochem Biophys Res Commun       Date:  2006-04-19       Impact factor: 3.575

9.  Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension.

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10.  Drosophila Smad2 opposes Mad signaling during wing vein development.

Authors:  Veronika Sander; Edward Eivers; Renee H Choi; Edward M De Robertis
Journal:  PLoS One       Date:  2010-04-28       Impact factor: 3.240
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