| Literature DB >> 9561195 |
B D Korant1, P Strack, M W Frey, C J Rizzo.
Abstract
Cleavage of non-viral proteins is rarely observed with the HIV-1 protease (HIV pr). One such cleavage event occurs with bcl-2, an important cytoprotective protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and programmed death of the host cell. A strategy is proposed to suppress HIV with non-cleavable mutants of bcl-2.Entities:
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Year: 1998 PMID： 9561195 DOI： 10.1007/978-1-4615-5373-1_3
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622