Literature DB >> 9560057

Expression of insulin-like growth factor-2 can predict the prognosis of human colorectal cancer patients: correlation with tumor progression, proliferative activity and survival.

K Kawamoto1, H Onodera, S Kondo, S Kan, D Ikeuchi, S Maetani, M Imamura.   

Abstract

Expression of insulin-like growth factor-2 (IGF-2) has been reported in tissue specimens and cell lines of human colorectal cancers. However, the effects of IGF-2 in colorectal cancer patients are not well known. In this study, IGF-2 staining was performed on tissue samples from 92 patients with colorectal cancer, and the relationship of IGF-2 staining to clinicopathological variables, proliferating cell nuclear antigen (PCNA) staining and patient survival was analyzed. IGF-2 staining was correlated with tumor progression, PCNA staining and patient survival. Our results suggest that IGF-2 plays an important role in tumor progression and that IGF-2 staining is useful as a prognostic factor in colorectal cancer patients.

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Year:  1998        PMID： 9560057     DOI： 10.1159/000011858

Source DB:  PubMed          Journal:  Oncology        ISSN： 0030-2414            Impact factor:   2.935


  23 in total

Review 1.  Estrogen Receptor-β and the Insulin-Like Growth Factor Axis as Potential Therapeutic Targets for Triple-Negative Breast Cancer.

Authors:  Nalo Hamilton; Diana Marquez-Garban; Vei H Mah; Yahya Elshimali; David Elashoff; Edward B Garon; Jaydutt Vadgama; Richard Pietras
Journal:  Crit Rev Oncog       Date:  2015

2.  Clinicopathological significance and impact on outcomes of the gene expression levels of IGF-1, IGF-2 and IGF-1R, IGFBP-3 in patients with colorectal cancer: Overexpression of the IGFBP-3 gene is an effective predictor of outcomes in patients with colorectal cancer.

Authors:  Naoto Yamamoto; Takashi Oshima; Kazue Yoshihara; Toru Aoyama; Tsutomu Hayashi; Takanobu Yamada; Tsutomu Sato; Manabu Shiozawa; Takaki Yoshikawa; Soichiro Morinaga; Yasushi Rino; Chikara Kunisaki; Katsuaki Tanaka; Makoto Akaike; Toshio Imada; Munetaka Masuda
Journal:  Oncol Lett       Date:  2017-03-28       Impact factor: 2.967

3.  Development of targeted therapy for a broad spectrum of cancers (pancreatic cancer, ovarian cancer, glioblastoma and HCC) mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences.

Authors:  Doron Amit; Abraham Hochberg
Journal:  Int J Clin Exp Med       Date:  2012-08-22

4.  Fas/CD95 signaling rather than angiogenesis or proliferative activity is a useful prognostic factor in patients with resected liver metastases from colorectal cancer.

Authors:  Hisashi Onodera; Akira Mori; Satoshi Nagayama; Akihisa Fujimoto; Tsuyoshi Tachibana; Yoshikuni Yonenaga; Tatsuaki Tsuruyama
Journal:  Int J Colorectal Dis       Date:  2005-04-22       Impact factor: 2.571

5.  A Phase IIa Trial of Metformin for Colorectal Cancer Risk Reduction among Individuals with History of Colorectal Adenomas and Elevated Body Mass Index.

Authors:  Jason A Zell; Christine E McLaren; Timothy R Morgan; Michael J Lawson; Sherif Rezk; C Gregory Albers; Wen-Pin Chen; Joseph C Carmichael; Jinah Chung; Ellen Richmond; L M Rodriguez; Eva Szabo; Leslie G Ford; Michael N Pollak; Frank L Meyskens
Journal:  Cancer Prev Res (Phila)       Date:  2019-12-09

6.  The correlation between IGF-II and Bcl-2 expression in colorectal adenocarcinoma.

Authors:  Ming-Sheng Zhang; Ai-Hua Hu; Hong Qiu; Hui-Hua Xiong; Yuan Chen
Journal:  Med Oncol       Date:  2011-03-06       Impact factor: 3.064

7.  IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer.

Authors:  Gerrit Peters; Silvia Gongoll; Cord Langner; Michael Mengel; Pompiliu Piso; Jürgen Klempnauer; Josef Rüschoff; Hans Kreipe; Reinhard von Wasielewski
Journal:  Virchows Arch       Date:  2003-07-05       Impact factor: 4.064

8.  IGF2 knockdown in two colorectal cancer cell lines decreases survival, adhesion and modulates survival-associated genes.

Authors:  Michael A Rogers; Verena Kalter; Moritz Strowitzki; Martin Schneider; Peter Lichter
Journal:  Tumour Biol       Date:  2016-06-23

9.  Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets.

Authors:  Lin Yang; Li Zhang; Qiuyu Wu; Douglas D Boyd
Journal:  J Biol Chem       Date:  2008-10-21       Impact factor: 5.157

10.  High IGF1R protein expression correlates with disease-free survival of patients with stage III colon cancer.

Authors:  Aziz Zaanan; Claire Calmel; Julie Henriques; Magali Svrcek; Hélène Blons; Christèle Desbois-Mouthon; Fatiha Merabtene; Claire Goumard; Yann Parc; Brice Gayet; Julien Taieb; Pierre Validire; Christophe Louvet; Jean-François Fléjou; Yves Le Bouc; Françoise Praz
Journal:  Cell Oncol (Dordr)       Date:  2019-12-10       Impact factor: 6.730
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