| Literature DB >> 9559267 |
M Schwarz1, E G Lund, D W Russell.
Abstract
The addition of a 7-hydroxyl group is an early and often rate-limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7 alpha-hydroxylase and oxysterol 7 alpha-hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7 alpha-hydroxylated bile acids.Entities:
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Year: 1998 PMID： 9559267 DOI： 10.1097/00041433-199804000-00006
Source DB: PubMed Journal: Curr Opin Lipidol ISSN： 0957-9672 Impact factor: 4.776