| Literature DB >> 9557689 |
L D Strockbine1, J I Cohen, T Farrah, S D Lyman, F Wagener, R F DuBose, R J Armitage, M K Spriggs.
Abstract
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus associated with infectious mononucleosis and several tumors. The BARF1 gene is transcribed early after EBV infection from the BamHI A fragment of the EBV genome. Evidence shown here indicates that the BARF1 protein is secreted into the medium of transfected cells and from EBV-carrying B cells induced to allow lytic replication of the virus. Expression cloning identified colony-stimulating factor-1 (CSF-1) as a ligand for BARF1. Computer-assisted analyses indicated that subtle amino acid sequence homology exists between BARF1 and c-fins, the cellular proto-oncogene that is the receptor for CSF-1. Recombinant BARF1 protein was found to be biologically active, and it neutralized the proliferative effects of human CSF-1 in a dose-dependent fashion when assayed in vitro. Since CSF-1 is a pleiotropic cytokine best known for its differentiating effects on macrophages, these data suggest that BARF1 may function to modulate the host immune response to EBV infection.Entities:
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Year: 1998 PMID： 9557689 PMCID： PMC109629 DOI： 10.1128/JVI.72.5.4015-4021.1998
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103