| Literature DB >> 9555019 |
H Tanimukai1, K Imaizumi, T Kudo, T Katayama, M Tsuda, T Takagi, M Tohyama, M Takeda.
Abstract
To investigate the biological roles of the presenilin-1 (PS-1) gene after neuronal injury, the changes of PS-1 mRNA expression in the gerbil hippocampus after transient ischemia were examined. From 1 day to 3 day-reperfusion after 5 min-ischemia, PS-1 mRNA was induced in the hippocampus compared with the sham-operated control. The cells which induced the PS-1 genes were neurons of CA3 and dentate gyrus, the region relatively resistant to ischemic stress. These findings suggest that the induction of PS-1 genes may be associated with some responses of neurons damaged by transient ischemia. Copyright 1998 Elsevier Science B.V.Entities:
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Year: 1998 PMID： 9555019 DOI： 10.1016/s0169-328x(97)00337-9
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X