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Literature DB >> 9553043

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination.

Abstract

RecQ helicase is important to homologous recombination and DNA repair in Escherichia coli. We demonstrate that RecQ helicase, in conjunction with RecA and SSB proteins, can initiate recombination events in vitro. In addition, RecQ protein is capable of unwinding a wide variety of DNA substrates, including joint molecules formed by RecA protein. These data are consistent with RecQ helicase assuming two roles in the cell; it can be (1) an initiator of homologous recombination, or (2) a disrupter of joint molecules formed by aberrant recombination. These findings also shed light on the function of the eukaryotic homologs of RecQ helicase, the Sgs1, Blm, and Wrn helicases.

Entities: Gene Species

Mesh：

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Year: 1998 PMID： 9553043 PMCID： PMC316708 DOI： 10.1101/gad.12.8.1134

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

56 in total

1. Genetic control of recombination exchange frequency in Escherichia coli K-12.

Authors: V Lanzov; I Stepanova; G Vinogradskaja
Journal: Biochimie Date: 1991 Feb-Mar Impact factor: 4.079

2. Homologous pairing in vitro stimulated by the recombination hotspot, Chi.

Authors: D A Dixon; S C Kowalczykowski
Journal: Cell Date: 1991-07-26 Impact factor: 41.582

3. Escherichia coli RecQ protein is a DNA helicase.

Authors: K Umezu; K Nakayama; H Nakayama
Journal: Proc Natl Acad Sci U S A Date: 1990-07 Impact factor: 11.205

4. DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.

Authors: N Suzuki; A Shimamoto; O Imamura; J Kuromitsu; S Kitao; M Goto; Y Furuichi
Journal: Nucleic Acids Res Date: 1997-08-01 Impact factor: 16.971

5. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest.

Authors: E Stewart; C R Chapman; F Al-Khodairy; A M Carr; T Enoch
Journal: EMBO J Date: 1997-05-15 Impact factor: 11.598

Review 6. Homologous recombination in procaryotes.

Authors: G R Smith
Journal: Microbiol Rev Date: 1988-03

7. RecBCD-dependent joint molecule formation promoted by the Escherichia coli RecA and SSB proteins.

Authors: L J Roman; D A Dixon; S C Kowalczykowski
Journal: Proc Natl Acad Sci U S A Date: 1991-04-15 Impact factor: 11.205

8. The Bloom's syndrome gene product is a 3'-5' DNA helicase.

Authors: J K Karow; R K Chakraverty; I D Hickson
Journal: J Biol Chem Date: 1997-12-05 Impact factor: 5.157

9. The Werner syndrome protein is a DNA helicase.

Authors: M D Gray; J C Shen; A S Kamath-Loeb; A Blank; B L Sopher; G M Martin; J Oshima; L A Loeb
Journal: Nat Genet Date: 1997-09 Impact factor: 38.330

10. Effects of the Escherichia coli SSB protein on the binding of Escherichia coli RecA protein to single-stranded DNA. Demonstration of competitive binding and the lack of a specific protein-protein interaction.

Authors: S C Kowalczykowski; J Clow; R Somani; A Varghese
Journal: J Mol Biol Date: 1987-01-05 Impact factor: 5.469

104 in total

9. Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.

Authors: P Pichierri; A Franchitto; P Mosesso; F Palitti
Journal: Mol Biol Cell Date: 2001-08 Impact factor: 4.138

10. Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

Authors: J C Shen; L A Loeb
Journal: Nucleic Acids Res Date: 2000-09-01 Impact factor: 16.971

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination.

1. Genetic control of recombination exchange frequency in Escherichia coli K-12.

2. Homologous pairing in vitro stimulated by the recombination hotspot, Chi.

3. Escherichia coli RecQ protein is a DNA helicase.

4. DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.

5. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest.

Review 6. Homologous recombination in procaryotes.

7. RecBCD-dependent joint molecule formation promoted by the Escherichia coli RecA and SSB proteins.

8. The Bloom's syndrome gene product is a 3'-5' DNA helicase.

9. The Werner syndrome protein is a DNA helicase.

10. Effects of the Escherichia coli SSB protein on the binding of Escherichia coli RecA protein to single-stranded DNA. Demonstration of competitive binding and the lack of a specific protein-protein interaction.

1. Illegitimate recombination induced by overproduction of DnaB helicase in Escherichia coli.

2. Palindromes as substrates for multiple pathways of recombination in Escherichia coli.

3. The Bloom's syndrome gene product promotes branch migration of holliday junctions.

4. Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase.

5. UvrA and UvrB suppress illegitimate recombination: synergistic action with RecQ helicase.

6. The Aspergillus nidulans musN gene encodes a RecQ helicase that interacts with the PI-3K-related kinase UVSB.

7. The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.

8. Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1.

9. Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.

10. Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.