| Literature DB >> 9552391 |
S H Kim1, U Schulze-Gahmen, J Brandsen, W F de Azevedo Júnior.
Abstract
The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for discovering small inhibitory molecules that can modify the degree of cell proliferation. The three-dimensional structure of CDK2 provides a structural foundation for understanding the mechanisms of activation and inhibition of CDK2 and for the discovery of inhibitors. In this article five structures of human CDK2 are summarised: apoprotein, ATP complex, olomoucine complex, isopentenyladenine complex, and des-chloro-flavopiridol complex.Entities:
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Year: 1996 PMID： 9552391 DOI： 10.1007/978-1-4615-5873-6_14
Source DB: PubMed Journal: Prog Cell Cycle Res ISSN： 1087-2957