Literature DB >> 9552362

The Cdc28 inhibitor p40SIC1.

M D Mendenhall1, W al-Jumaily, T T Nugroho.   

Abstract

Sic1 inhibits the activity of Cdc28.Clb5 complexes in late G1, creating a delay between cell cycle commitment and S phase initiation. The ultimate purpose of this delay is unknown but loss of Sic1 activity negatively affects genomic stability and cellular viability. Sic1 levels are controlled by periodic changes in transcription rates and protein stability. The latter control is mediated through the Cdc34 ubiquitin transferase and, possibly, Cdc28.Cln activity. Possible roles of Sic1 in the G1/S and the M/G1 transitions are discussed.

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Year:  1995        PMID： 9552362     DOI： 10.1007/978-1-4615-1809-9_14

Source DB:  PubMed          Journal:  Prog Cell Cycle Res        ISSN： 1087-2957


  8 in total

1.  The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae.

Authors:  Ritu Pathak; Heidi M Blank; Jinbai Guo; Sarah Ellis; Michael Polymenis
Journal:  Biochem Biophys Res Commun       Date:  2007-07-26       Impact factor: 3.575

2.  Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles.

Authors:  P K Vinod; Paula Freire; Ahmed Rattani; Andrea Ciliberto; Frank Uhlmann; Bela Novak
Journal:  J R Soc Interface       Date:  2011-02-02       Impact factor: 4.118

3.  The Spo12 protein of Saccharomyces cerevisiae: a regulator of mitotic exit whose cell cycle-dependent degradation is mediated by the anaphase-promoting complex.

Authors:  R Shah; S Jensen; L M Frenz; A L Johnson; L H Johnston
Journal:  Genetics       Date:  2001-11       Impact factor: 4.562

4.  Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle.

Authors:  M Weinreich; C Liang; H H Chen; B Stillman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

5.  The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain.

Authors:  Matteo Barberis; Luca De Gioia; Maria Ruzzene; Stefania Sarno; Paola Coccetti; Piercarlo Fantucci; Marco Vanoni; Lilia Alberghina
Journal:  Biochem J       Date:  2005-05-01       Impact factor: 3.857

6.  Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107.

Authors:  Taku Chibazakura; Seth G McGrew; Jonathan A Cooper; Hirofumi Yoshikawa; James M Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-15       Impact factor: 11.205

Review 7.  Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.

Authors:  M D Mendenhall; A E Hodge
Journal:  Microbiol Mol Biol Rev       Date:  1998-12       Impact factor: 11.056

8.  A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division.

Authors:  Scott A Hoose; Jeremy A Rawlings; Michelle M Kelly; M Camille Leitch; Qotaiba O Ababneh; Juan P Robles; David Taylor; Evelyn M Hoover; Bethel Hailu; Kayla A McEnery; S Sabina Downing; Deepika Kaushal; Yi Chen; Alex Rife; Kirtan A Brahmbhatt; Roger Smith; Michael Polymenis
Journal:  PLoS Genet       Date:  2012-03-15       Impact factor: 5.917
  8 in total

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