Literature DB >> 9552320

Improvement of the material motion in a rotary processor.

J Vertommen1, B Jaucot, P Rombaut, R Kinget.   

Abstract

The purpose of this paper is to reject or to confirm the hypothesis that the influence of the water addition rate on the size and size distribution of pellets is caused by insufficient spreading of the added water at higher water addition rates. To overcome insufficient spreading of the added water, the agitation in the rotary processor is intensified by improving the spiral, rope-like movement by means of two baffles and a permanent PTFE coating, and by installing a chopper. Improvement of the spiral, rope-like movement moderates the influence of the water addition rate on the pellet size. The chopper has no significant influence on pellet size, pellet size distribution, or percentage of agglomerates for the pellets, which are investigated in this study. Furthermore, the implementation of the technical modifications does not influence the dissolution characteristics of the pellets directly. It is therefore concluded that the water added is well spread over the mass by ensuring an optimal spiral, rope-like movement, so that incorporation of a chopper is superfluous. The remaining influence of the water addition rate on the pellet size can most probably be explained by differences in processing time, resulting in different volumes of air capable of extracting water from the powder mass.

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Year:  1996        PMID: 9552320     DOI: 10.3109/10837459609031431

Source DB:  PubMed          Journal:  Pharm Dev Technol        ISSN: 1083-7450            Impact factor:   3.133


  1 in total

1.  Direct pelletization in a rotary processor controlled by torque measurements. II: effects of changes in the content of microcrystalline cellulose.

Authors:  J Kristensen; T Schaefer; P Kleinebudde
Journal:  AAPS PharmSci       Date:  2000
  1 in total

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