Literature DB >> 9551546

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

D Barford1, B G Neel.   

Abstract

The crystal structure of the protein tyrosine phosphatase SHP-2 reveals the mechanism of auto-inhibition of phosphatase activity by its SH2 domains. Phosphotyrosine peptide stimulation of the phosphatase activity, resulting from peptide binding to the N-terminal SH2 domain, is linked to conformational changes within the protein, including an unprecedented allosteric transition of the N-terminal SH2 domain.

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Year:  1998        PMID： 9551546     DOI： 10.1016/s0969-2126(98)00027-6

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  89 in total

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3.  Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

Authors:  Si Qing Zhang; William G Tsiaras; Toshiyuki Araki; Gengyun Wen; Liliana Minichiello; Ruediger Klein; Benjamin G Neel
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

Review 4.  B cell inhibitory receptors and autoimmunity.

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Journal:  Immunology       Date:  2003-03       Impact factor: 7.397

5.  Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases.

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6.  Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity.

Authors:  Christopher C Stebbins; Carsten Watzl; Daniel D Billadeau; Paul J Leibson; Deborah N Burshtyn; Eric O Long
Journal:  Mol Cell Biol       Date:  2003-09       Impact factor: 4.272

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Authors:  Maria I Kontaridis; Seda Eminaga; Mara Fornaro; Christina Ivins Zito; Raffaella Sordella; Jeffrey Settleman; Anton M Bennett
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

8.  Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

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9.  Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.

Authors:  Hong Zheng; Wen-Mei Yu; Ronald R Waclaw; Maria I Kontaridis; Benjamin G Neel; Cheng-Kui Qu
Journal:  Sci Signal       Date:  2018-03-20       Impact factor: 8.192

10.  Reactive oxygen species play a critical role in collagen-induced platelet activation via SHP-2 oxidation.

Authors:  Ji Yong Jang; Ji Hyun Min; Yun Hee Chae; Jin Young Baek; Su Bin Wang; Su Jin Park; Goo Taeg Oh; Sang-Hak Lee; Ye-Shih Ho; Tong-Shin Chang
Journal:  Antioxid Redox Signal       Date:  2014-01-30       Impact factor: 8.401
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