Psychopathologic domains and insight in schizophrenia.

The earlier conceptualization of positive and negative symptom topologies for schizophrenia has given way to more complex models that propose three-and-four dimensions of psychopathology. These constructs may relate to neurobiologic heterogeneity and discrete symptom clusters have been shown to have distinct anatomical and cognitive correlates. Insight is an excellent example and the understanding of insight at psychopathologic and cognitive levels has facilitated new approaches to treatment and enhanced medication compliance.