The new epidemiology of schizophrenia.

A confluence of findings from different vantage points has led to renewed interest and direction in the epidemiology of schizophrenia. This article provides an overview of prevalence and incidence data, examining the validity of reported secular trends in the occurrence of schizophrenia. Advances in molecular genetics have uncovered new linkage on chromosomes 6, 8, and 22 and have suggested complex models, including anticipation, to explain the perpetuation of genetic transmission in the face of low fecundity. Neurotropic viruses and autoimmunity have emerged as pathoplastic mechanisms to explain recent intriguing epidemiologic associations in schizophrenia. Environmental risk factors are also important. With attention to particular risk factors (i.e., perinatal hypoxia), a preventative approach may be realistic for some forms of schizophrenia.