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Review 1. Targeting opioid receptor heterodimers: strategies for screening and drug development.

Authors: Achla Gupta; Fabien M Décaillot; Lakshmi A Devi
Journal: AAPS J Date: 2006-03-10 Impact factor: 4.009

2. Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.

Authors: Tingyou Li; Kimitaka Shiotani; Anna Miyazaki; Yuko Tsuda; Akihiro Ambo; Yusuke Sasaki; Yunden Jinsmaa; Ewa Marczak; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Journal: J Med Chem Date: 2007-05-12 Impact factor: 7.446

3. Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show in Vitro Kappa and Mu Opioid Receptor Agonism.

Authors: Deanna Montgomery; Jessica P Anand; Nicholas W Griggs; Thomas J Fernandez; Joshua G Hartman; Ashley A Sánchez-Santiago; Irina D Pogozheva; John R Traynor; Henry I Mosberg
Journal: ACS Chem Neurosci Date: 2019-07-01 Impact factor: 4.418

New delta-opioid antagonists as pharmacological probes.

Review 1. Targeting opioid receptor heterodimers: strategies for screening and drug development.

2. Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.

3. Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show in Vitro Kappa and Mu Opioid Receptor Agonism.

4. Chiral Effect of a Phe Residue in Position 3 of the Dmt¹-L(or D)-Tic² Analogues on Opioid Functional Activities.

Review 5. Developmental potential for endomorphin opioidmimetic drugs.

Review 6. 2',6'-dimethylphenylalanine: a useful aromatic amino Acid surrogate for tyr or phe residue in opioid peptides.

New delta-opioid antagonists as pharmacological probes.

Review 1. Targeting opioid receptor heterodimers: strategies for screening and drug development.

2. Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.

3. Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show in Vitro Kappa and Mu Opioid Receptor Agonism.

4. Chiral Effect of a Phe Residue in Position 3 of the Dmt1-L(or D)-Tic2 Analogues on Opioid Functional Activities.

Review 5. Developmental potential for endomorphin opioidmimetic drugs.

Review 6. 2',6'-dimethylphenylalanine: a useful aromatic amino Acid surrogate for tyr or phe residue in opioid peptides.

4. Chiral Effect of a Phe Residue in Position 3 of the Dmt¹-L(or D)-Tic² Analogues on Opioid Functional Activities.