Literature DB >> 9548435

Induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide.

K Takegawa1, K Mitsumori, H Onodera, K Yasuhara, K Kitaura, T Shimo, M Takahashi.   

Abstract

In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high-dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non-genotoxic, proliferation-dependent mechanism.

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Year:  1998        PMID： 9548435      PMCID： PMC5921766          DOI： 10.1111/j.1349-7006.1998.tb00536.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  23 in total

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4.  Iodide mumps following intravenous urography with iopamidol.

Authors:  E J Wylie; D B Mitchell
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5.  Lack of toxicity/carcinogenicity of monosodium succinate in F344 rats.

Authors:  A Maekawa; A Todate; H Onodera; Y Matsushima; T Nagaoka; M Shibutani; H Ogasawara; Y Kodama; Y Hayashi
Journal:  Food Chem Toxicol       Date:  1990-04       Impact factor: 6.023

6.  Carcinogenicity study of tetramethylthiuram disulfide (thiram) in F344 rats.

Authors:  R Hasegawa; M Takahashi; F Furukawa; K Toyoda; H Sato; J J Jang; Y Hayashi
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7.  Sialadenitis following I-131 therapy for thyroid carcinoma: concise communication.

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8.  Carcinogenicity study of sodium hypochlorite in F344 rats.

Authors:  R Hasegawa; M Takahashi; T Kokubo; F Furukawa; K Toyoda; H Sato; Y Kurokawa; Y Hayashi
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Authors:  J E Boers; G P ten Velde; F B Thunnissen
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10.  Dose-response carcinogenicity in rats on low-dose levels of N-ethyl-N-nitrosourethane.

Authors:  A Maekawa; H Onodera; Y Matsushima; T Nagaoka; A Todate; M Shibutani; Y Kodama; Y Hayashi
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  4 in total

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Journal:  J Toxicol Pathol       Date:  2016-02-13       Impact factor: 1.628

3.  Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model.

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Journal:  Biomed Res Int       Date:  2017-11-08       Impact factor: 3.411

4.  Squamous Metaplasia in Pleomorphic Adenoma: A Diagnostic and Prognostic Enigma.

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  4 in total

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