Literature DB >> 9548391

The effect of chronic L-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats.

H Rauchová1, Z Dobesová, Z Drahota, J Zicha, J Kunes.   

Abstract

The effect of chronic L-carnitine treatment on blood pressure and plasma lipids was studied in spontaneously hypertensive rats (SHR). L-Carnitine treatment for 6 weeks lowered significantly both the systolic and mean arterial pressure of SHR but its influence on diastolic and pulse pressure was only modest. L-Carnitine did not influence the relative heart and kidney weight of SHR. However, L-carnitine completely abolished the age-dependent rise of plasma total cholesterol, triglycerides and uric acid seen in untreated SHR. On the other hand, L-carnitine treatment had no significant effects on blood pressure, relative organ weight and plasma lipids in normotensive Wistar-Kyoto rats. Our results suggest that L-carnitine might prevent some cardiovascular alterations by its influence on lipid metabolism.

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Year:  1998        PMID： 9548391     DOI： 10.1016/s0014-2999(97)01505-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

1.  Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension.

Authors:  Alfonso Mate; José L Miguel-Carrasco; María T Monserrat; Carmen M Vázquez
Journal:  J Physiol Biochem       Date:  2010-05-27       Impact factor: 4.158

2.  L-carnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA study.

Authors:  Catharina M C Mels; Aletta E Schutte; Elardus Erasmus; Hugo W Huisman; Rudolph Schutte; Carla M T Fourie; Ruan Kruger; Johannes M Van Rooyen; Wayne Smith; Nicolaas T Malan; Leoné Malan
Journal:  Lipids       Date:  2012-10-26       Impact factor: 1.880

3.  L-carnitine transport in kidney of normotensive, Wistar-Kyoto rats: effect of chronic L-carnitine administration.

Authors:  Lucía Gómez-Amores; Alfonso Mate; Carmen M Vázquez
Journal:  Pharm Res       Date:  2003-08       Impact factor: 4.200

4.  Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.

Authors:  Melanie Kolz; Toby Johnson; Serena Sanna; Alexander Teumer; Veronique Vitart; Markus Perola; Massimo Mangino; Eva Albrecht; Chris Wallace; Martin Farrall; Asa Johansson; Dale R Nyholt; Yurii Aulchenko; Jacques S Beckmann; Sven Bergmann; Murielle Bochud; Morris Brown; Harry Campbell; John Connell; Anna Dominiczak; Georg Homuth; Claudia Lamina; Mark I McCarthy; Thomas Meitinger; Vincent Mooser; Patricia Munroe; Matthias Nauck; John Peden; Holger Prokisch; Perttu Salo; Veikko Salomaa; Nilesh J Samani; David Schlessinger; Manuela Uda; Uwe Völker; Gérard Waeber; Dawn Waterworth; Rui Wang-Sattler; Alan F Wright; Jerzy Adamski; John B Whitfield; Ulf Gyllensten; James F Wilson; Igor Rudan; Peter Pramstaller; Hugh Watkins; Angela Doering; H-Erich Wichmann; Tim D Spector; Leena Peltonen; Henry Völzke; Ramaiah Nagaraja; Peter Vollenweider; Mark Caulfield; Thomas Illig; Christian Gieger
Journal:  PLoS Genet       Date:  2009-06-05       Impact factor: 5.917

5.  Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease.

Authors:  Craig J McMackin; Michael E Widlansky; Naomi M Hamburg; Alex L Huang; Susan Weller; Monika Holbrook; Noyan Gokce; Tory M Hagen; John F Keaney; Joseph A Vita
Journal:  J Clin Hypertens (Greenwich)       Date:  2007-04       Impact factor: 3.738
  5 in total

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