H Gjønnaess1. 1. Department of Gynecology, Aker University Hospital, Oslo, Norway.
Abstract
OBJECTIVE: To examine the duration of the changes in endocrine indices produced by ovarian electrocautery in women with polycystic ovary syndrome (PCOS). DESIGN: Long-term observational study. SETTING: University hospital. PATIENT(S): Infertile women with PCOS. INTERVENTION(S): Ovarian electrocautery was performed through the laparoscope. Blood was sampled before the operation and at defined intervals thereafter. After the establishment of regular cycles, sampling was performed 1 week before the menstrual period. MAIN OUTCOME MEASURE(S): The patients were observed before and at defined intervals for up to 20 years after ovarian electrocautery. Serum concentrations of hypophyseal and ovarian hormones were determined, including sex hormone-binding globulin (SHBG). RESULT(S): There was a clear shift from anovulation to ovulatory cycles and a significant decrease in androgens and gonadotropins. The concentration of SHBG increased. These effects lasted for many years; after 18-20 years, two thirds of the women were still ovulating. CONCLUSION(S): Ovarian electrocautery for PCOS normalizes ovarian function, including androgen production, and the results seem to be stable for 18-20 years.
OBJECTIVE: To examine the duration of the changes in endocrine indices produced by ovarian electrocautery in women with polycystic ovary syndrome (PCOS). DESIGN: Long-term observational study. SETTING: University hospital. PATIENT(S): Infertile women with PCOS. INTERVENTION(S): Ovarian electrocautery was performed through the laparoscope. Blood was sampled before the operation and at defined intervals thereafter. After the establishment of regular cycles, sampling was performed 1 week before the menstrual period. MAIN OUTCOME MEASURE(S): The patients were observed before and at defined intervals for up to 20 years after ovarian electrocautery. Serum concentrations of hypophyseal and ovarian hormones were determined, including sex hormone-binding globulin (SHBG). RESULT(S): There was a clear shift from anovulation to ovulatory cycles and a significant decrease in androgens and gonadotropins. The concentration of SHBG increased. These effects lasted for many years; after 18-20 years, two thirds of the women were still ovulating. CONCLUSION(S): Ovarian electrocautery for PCOS normalizes ovarian function, including androgen production, and the results seem to be stable for 18-20 years.
Authors: Carolina Ortega-Hrepich; Nikolaos P Polyzos; Ellen Anckaert; Luis Guzman; Herman Tournaye; Johan Smitz; Michel De Vos Journal: Reprod Biol Endocrinol Date: 2014-02-24 Impact factor: 5.211