Literature DB >> 9547348

Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene.

P Honkakoski1, R Moore, K A Washburn, M Negishi.   

Abstract

By extending previous studies of the phenobarbital (PB)-responsive 132-base pair (bp) enhancer sequence in the CYP2B10 gene, we have delimited a 51-bp enhancer element that is fully inducible by PB in mouse primary hepatocytes. Sixteen structurally unrelated phenobarbital-type inducers activated the 51-bp enhancer element in transient transfection assays. The results thus indicate that most PB-type inducers, if not all inducers, increase the transcription of the CYP2B10 gene by activating this 51-bp element, now designated PB-responsive enhancer module or PBREM.

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Year:  1998        PMID： 9547348     DOI： 10.1124/mol.53.4.597

Source DB:  PubMed          Journal:  Mol Pharmacol        ISSN： 0026-895X            Impact factor:   4.436


  35 in total

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Review 3.  Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.

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5.  Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice.

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Journal:  Biochem J       Date:  2005-06-15       Impact factor: 3.857

6.  Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene.

Authors:  T Kawamoto; T Sueyoshi; I Zelko; R Moore; K Washburn; M Negishi
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

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8.  Human PXR forms a tryptophan zipper-mediated homodimer.

Authors:  Schroeder M Noble; Virginia E Carnahan; Linda B Moore; Tom Luntz; Hongbing Wang; Olivia R Ittoop; Julie B Stimmel; Paula R Davis-Searles; Ryan E Watkins; G Bruce Wisely; Ed LeCluyse; Ashutosh Tripathy; Donald P McDonnell; Matthew R Redinbo
Journal:  Biochemistry       Date:  2006-07-18       Impact factor: 3.162

Review 9.  CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme.

Authors:  Hongbing Wang; Leslie M Tompkins
Journal:  Curr Drug Metab       Date:  2008-09       Impact factor: 3.731

Review 10.  Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

Authors:  Hongbing Wang; Edward L LeCluyse
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447
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