Literature DB >> 9546787

Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination.

R Cheynier1, S Gratton, M Halloran, I Stahmer, N L Letvin, S Wain-Hobson.   

Abstract

The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCG inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV variant was noted, probably as a result of the infiltration of activated antigen-specific T cell clones as opposed to infection by blood borne virus in situ. The dynamics of SIV quasispecies in peripheral blood suggests sequential waves of viral replication, illustrating the role of antigenic stimulation as a driving force in viral dissemination and pathogenesis.

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Year:  1998        PMID： 9546787     DOI： 10.1038/nm0498-421

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  17 in total

1.  Combined megaplex TCR isolation and SMART-based real-time quantitation methods for quantitating antigen-specific T cell clones in mycobacterial infection.

Authors:  George Du; Liyou Qiu; Ling Shen; Probhat Sehgal; Yun Shen; Dan Huang; Norman L Letvin; Zheng W Chen
Journal:  J Immunol Methods       Date:  2005-11-15       Impact factor: 2.303

2.  BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial.

Authors:  Melanie A Gasper; Anneke C Hesseling; Isaac Mohar; Landon Myer; Tali Azenkot; Jo-Ann S Passmore; Willem Hanekom; Mark F Cotton; I Nicholas Crispe; Donald L Sodora; Heather B Jaspan
Journal:  JCI Insight       Date:  2017-04-06

3.  Mycobacterial codon optimization enhances antigen expression and virus-specific immune responses in recombinant Mycobacterium bovis bacille Calmette-Guérin expressing human immunodeficiency virus type 1 Gag.

Authors:  Masaru Kanekiyo; Kazuhiro Matsuo; Makiko Hamatake; Takaichi Hamano; Takeaki Ohsu; Sohkichi Matsumoto; Takeshi Yamada; Shudo Yamazaki; Atsuhiko Hasegawa; Naoki Yamamoto; Mitsuo Honda
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

4.  The infiltration kinetics of simian immunodeficiency virus-specific T cells drawn to sites of high antigenic stimulation determines local in vivo viral escape.

Authors:  P Blancou; N Chenciner; M C Cumont; S Wain-Hobson; B Hurtrel; R Cheynier
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-30       Impact factor: 11.205

Review 5.  Animal models to study Mycobacterium tuberculosis and HIV co-infection.

Authors:  Ming Guo; Wen-Zhe Ho
Journal:  Dongwuxue Yanjiu       Date:  2014-05

6.  Induction of an AIDS virus-related tuberculosis-like disease in macaques: a model of simian immunodeficiency virus- mycobacterium coinfection.

Authors:  Yun Shen; Dejiang Zhou; Laura Chalifoux; Ling Shen; Meredith Simon; Xuejun Zeng; Xioamin Lai; Yunyuan Li; Prabhat Sehgal; Norman L Letvin; Zheng W Chen
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

7.  Dynamics of gamma interferon, interleukin-12 (IL-12), IL-10, and transforming growth factor beta mRNA expression in primary Mycobacterium bovis BCG infection in guinea pigs measured by a real-time fluorogenic reverse transcription-PCR assay.

Authors:  Mamoru Kawahara; Tadashi Nakasone; Mitsuo Honda
Journal:  Infect Immun       Date:  2002-12       Impact factor: 3.441

8.  Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasispecies.

Authors:  M A Ostrowski; D C Krakauer; Y Li; S J Justement; G Learn; L A Ehler; S K Stanley; M Nowak; A S Fauci
Journal:  J Virol       Date:  1998-10       Impact factor: 5.103

9.  A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection.

Authors:  M A Poles; J Elliott; P Taing; P A Anton; I S Chen
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

10.  Antigenic stimulation specifically reactivates the replication of archived simian immunodeficiency virus genomes in chronically infected macaques.

Authors:  Céline Renoux; Simon Wain-Hobson; Bruno Hurtrel; Rémi Cheynier
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103
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