Literature DB >> 9545335

RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation.

M E Engel1, P K Datta, H L Moses.   

Abstract

Transforming growth factor beta (TGF-beta) is the prototype for an evolutionarily conserved superfamily of secreted factors implicated in diverse biological phenomena. The pleiotropic responses to TGF-beta are initiated by a heteromeric receptor complex that binds and phosphorylates downstream effectors. Among these, the Smads have been extensively studied. However, less attention has been directed toward alternative downstream effectors and their participation in TGF-beta signal transduction. We show that TGF-beta promotes accumulation of the labile monomeric GTPase RhoB by antagonizing its normal proteolytic destruction, presumably via the 26 S proteasome. RhoB accumulates in its isoprenylated form. Transient overexpression of wild type RhoB but not its dominant negative mutant RhoB-N19 antagonizes TGF-beta-mediated transcriptional activation. These results suggest a novel mechanism of regulation by TGF-beta and implicate RhoB as a negative regulator of TGF-beta signal transduction.

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Year:  1998        PMID： 9545335     DOI： 10.1074/jbc.273.16.9921

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  30 in total

1.  RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage.

Authors:  G J Cerniglia; E J Bernhard; G C Prendergast
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

2.  CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells.

Authors:  Laurent Boyer; Laurent Turchi; Benoit Desnues; Anne Doye; Gilles Ponzio; Jean-Louis Mege; Motozo Yamashita; Ying E Zhang; Jacques Bertoglio; Gilles Flatau; Patrice Boquet; Emmanuel Lemichez
Journal:  Mol Biol Cell       Date:  2006-03-15       Impact factor: 4.138

3.  RHOB influences lung adenocarcinoma metastasis and resistance in a host-sensitive manner.

Authors:  Diego Luis-Ravelo; Iker Antón; Carolina Zandueta; Karmele Valencia; María-José Pajares; Jackeline Agorreta; Luis Montuenga; Silvestre Vicent; Ignacio I Wistuba; Javier De Las Rivas; Fernando Lecanda
Journal:  Mol Oncol       Date:  2013-11-12       Impact factor: 6.603

4.  RhoB deficiency in thymic medullary epithelium leads to early thymic atrophy.

Authors:  Arturo Bravo-Nuevo; Rebekah O'Donnell; Alexander Rosendahl; Jae Hoon Chung; Laura E Benjamin; Chikako Odaka
Journal:  Int Immunol       Date:  2011-08-23       Impact factor: 4.823

5.  The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer.

Authors:  Junfeng Xu; Lihui Li; Guangyang Yu; Wantao Ying; Qiang Gao; Wenjuan Zhang; Xianyu Li; Chen Ding; Yanan Jiang; Dongping Wei; Shengzhong Duan; Qunying Lei; Peng Li; Tieliu Shi; Xiaohong Qian; Jun Qin; Lijun Jia
Journal:  Mol Cell Proteomics       Date:  2014-12-24       Impact factor: 5.911

6.  MicroRNA-21 in glomerular injury.

Authors:  Jennifer Y Lai; Jinghui Luo; Christopher O'Connor; Xiaohong Jing; Viji Nair; Wenjun Ju; Ann Randolph; Iddo Z Ben-Dov; Regina N Matar; Daniel Briskin; Jiri Zavadil; Robert G Nelson; Thomas Tuschl; Frank C Brosius; Matthias Kretzler; Markus Bitzer
Journal:  J Am Soc Nephrol       Date:  2014-08-21       Impact factor: 10.121

7.  RhoA and RhoC differentially modulate estrogen receptor α recruitment, transcriptional activities, and expression in breast cancer cells (MCF-7).

Authors:  Emilie Malissein; Elise Meunier; Isabelle Lajoie-Mazenc; Claire Médale-Giamarchi; Florence Dalenc; Sophie F Doisneau-Sixou
Journal:  J Cancer Res Clin Oncol       Date:  2013-10-06       Impact factor: 4.553

8.  Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.

Authors:  N A Bhowmick; M Ghiassi; A Bakin; M Aakre; C A Lundquist; M E Engel; C L Arteaga; H L Moses
Journal:  Mol Biol Cell       Date:  2001-01       Impact factor: 4.138

9.  The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway.

Authors:  Dolores Pérez-Sala; Patricia Boya; Irene Ramos; Mónica Herrera; Konstantinos Stamatakis
Journal:  PLoS One       Date:  2009-12-02       Impact factor: 3.240

10.  The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migration.

Authors:  Anna Tsapara; Phillip Luthert; John Greenwood; Caroline S Hill; Karl Matter; Maria S Balda
Journal:  Mol Biol Cell       Date:  2010-01-20       Impact factor: 4.138
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