| Literature DB >> 9543730 |
D Point1, P Coudert, F Leal, C Rubat, V Sautou-Miranda, J Chopineau, J Couquelet.
Abstract
Some 4-benzoyl 3-hydroxy furan-2 (5H) ones (3a-d) and 2-amino 3-hydroxymethyl 4-aryl 4-oxo 2-butenoic acids (4a-h) have been synthesized. Compound 3c with an isobutyl substituent in the 5-position of the furan ring was the most effective (IC50 = 8.69 x 10(-4) M) in scavenging the superoxide anion. In vivo, 3c was also protective against reperfusion injury.Entities:
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Year: 1998 PMID： 9543730 DOI： 10.1016/s0014-827x(97)00012-8
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X