| Literature DB >> 9543724 |
A M Almerico1, P Diana, P Barraja, G Dattolo, F Mingoia, A G Loi, F Scintu, C Milia, I Puddu, P La Colla.
Abstract
Acyclic glycosidopyrroles of type 1, synthesized in good overall yields, were evaluated for anti-viral activity. Compound 10i was found to inhibit the HIV-1 replication at concentrations that were very close to those cytotoxic for MT-4 cells. Compounds 10a,f,i inhibited both strains HSV-1 and HSV-2 at concentrations slightly below those cytotoxic for Vero cells. However for this series of glycosidopyrroles some relationship between calculated log P values and the observed cytotoxicity was found.Entities:
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Year: 1998 PMID： 9543724 DOI： 10.1016/s0014-827x(97)00002-5
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X