Literature DB >> 954023

Tissue culture, protein and collagen synthesis in antibiotic sterilized canine heart valves.

C G McGregor, J F Bradley, J O McGee, D J Wheatley.   

Abstract

Viability of canine heart valve leaflet fibroblasts was assessed after varying periods of sterilization and storage in antibiotic-nutrient solution. Tissue culture and assessment of protein and collagen synthesis showed that tissue obtained under optimal conditions rarely retains viability beyond 3 weeks in antibiotic-nutrient solution and is severely impaired after 2 weeks. This casts serious doubts on viability in current clinical homograft valve practice.

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Year:  1976        PMID: 954023     DOI: 10.1093/cvr/10.3.389

Source DB:  PubMed          Journal:  Cardiovasc Res        ISSN: 0008-6363            Impact factor:   10.787


  2 in total

1.  Determining viability of fresh or cryopreserved homograft valves at implantation.

Authors:  L Gonzalez-Lavin; L B McGrath; S Amini; D Graf
Journal:  Heart Vessels       Date:  1987       Impact factor: 2.037

2.  Morphology of heart valves preserved by liquid nitrogen freezing.

Authors:  L C Armiger; R W Thomson; M G Strickett; B G Barratt-Boyes
Journal:  Thorax       Date:  1985-10       Impact factor: 9.139

  2 in total

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