Literature DB >> 954013

Randomized prospective trial comparing 5-fluorouracil (NSC-19893) to 5-fluorouracil and methyl-CCNU (NSC-95441) in advanced gastrointestinal cancer.

L H Baker, V K Vaitkevicius, E Gehan.   

Abstract

The Southwest Oncology Group has confirmed the superiority of 5-fluorouracil (5-FU) and methyl-CCNU versus 5-FU weekly as treatment for patients with advanced gastrointestinal cancers. The drug combination produced a PR rate of 29.3% compared to the single-drug arm rate of 10.6%; however, the two-drug arm produced much more toxicity. Despite the improved response rate no improvement in survival was observed.

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Year:  1976        PMID： 954013

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN： 0361-5960


  7 in total

1.  Performance Status in Cancer: Not Broken, But Time for an Upgrade?

Authors:  Jessica M Scott; Guro Stene; Elisabeth Edvardsen; Lee W Jones
Journal:  J Clin Oncol       Date:  2020-06-25       Impact factor: 44.544

Review 2.  Update in cancer chemotherapy: gastrointestinal cancer, cancer of the stomach and carcinoid tumors.

Authors:  J C Wright
Journal:  J Natl Med Assoc       Date:  1986-07       Impact factor: 1.798

3.  Clinical trials in colorectal cancer: experience of the Gastrointestinal Tumor Study Group and the Southwest Oncology Group.

Authors:  R M Bukowski
Journal:  Int J Colorectal Dis       Date:  1987-06       Impact factor: 2.571

4.  Update in cancer chemotherapy: gastrointestinal cancer--colorectal cancer, Part 2.

Authors:  J C Wright
Journal:  J Natl Med Assoc       Date:  1986-05       Impact factor: 1.798

5.  Improved combination chemotherapy in advanced gastric cancer.

Authors:  J A Levi; D N Dalley; R S Aroney
Journal:  Br Med J       Date:  1979-12-08

6.  Antitumor activity of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea (MeCCNU) on Yoshida sarcoma ascites cells implanted into the colon wall of rats.

Authors:  S Bhide; M Habs; H Reinbold; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1979-05-14       Impact factor: 4.553

Review 7.  Chemotherapy and radiotherapy for advanced pancreatic cancer.

Authors:  Venessa Chin; Adnan Nagrial; Katrin Sjoquist; Chelsie A O'Connor; Lorraine Chantrill; Andrew V Biankin; Rob Jpm Scholten; Desmond Yip
Journal:  Cochrane Database Syst Rev       Date:  2018-03-20
  7 in total

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