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Literature DB >> 9540070

Further characterization of human RNase MRP/RNase P and related autoantibodies.

Abstract

We characterized a panel of human RNase MRP/RNase P autoantibodies by immunoprecipitation, immunodepletion, immunoaffinity purification and immunoblotting. We report on the protein spectrum that is recognized by RNase MRP/RNase P autoantibodies. We also describe another, related patient serum that based on these assays does not immunoprecipitate RNase P/MRP/Th40. This autoantibody 'KC', however, coimmunoprecipitates the RNase MRP/RNase P associated RNAs from HeLa and La9 cell extracts as shown by nuclease protection experiments.

Entities: Gene Species

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Year: 1998 PMID： 9540070 DOI： 10.1023/a:1006878511162

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

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References

29 in total

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Authors: S Altman
Journal: Biotechnology (N Y) Date: 1995-04

6. A functional dominant mutation in Schizosaccharomyces pombe RNase MRP RNA affects nuclear RNA processing and requires the mitochondrial-associated nuclear mutation ptp1-1 for viability.

Authors: J L Paluh; D A Clayton
Journal: EMBO J Date: 1996-09-02 Impact factor: 11.598

Further characterization of human RNase MRP/RNase P and related autoantibodies.

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