OBJECTIVE: To study diabetic and nondiabetic patients with their first myocardial infarction to determine overall 1-year mortality, out-of-hospital mortality, 28-day mortality of hospitalized patients, and 1-year mortality of 28-day survivors. RESEARCH DESIGN AND METHODS: This study--based on the FINMONICA Myocardial Infarction Register, a part of the Finnish contribution to the WHO MONICA Project (World Health Organization Multinational Monitoring of Trends and Determinants of Cardiovascular Disease)--covered coronary heart disease (CHD) deaths and acute CHD events occurring during hospitalization among residents of Finland aged 25-64 years in three geographically defined areas. The study population comprised 620 diabetic and 3,445 nondiabetic patients who had their first myocardial infarction during the years 1988-1992. RESULTS: The age- and area-adjusted mortality rates and hazard ratios (HRs) for diabetic versus nondiabetic patients (95% CI) were as follows: The 1-year mortality rate was 44.2% in diabetic men and 32.6% in nondiabetic men (HR, 1.38; 1.18-1.61) and 36.9% in diabetic women and 20.2% in nondiabetic women (HR, 1.86; 1.40-2.46); the out-of-hospital mortality rate was 28.3% in diabetic men and 22.4% in nondiabetic men (HR, 1.25; 1.03-1.52) and 10.4% in diabetic women and 11.0% in nondiabetic women (HR, 0.95; 0.58-1.54); the 28-day mortality rate of hospitalized patients was 14.4% in diabetic men and 8.8% in nondiabetic men (HR, 1.58; 1.15-2.18) and 21.7% in diabetic women and 7.8% in nondiabetic women (HR, 2.60; 1.71-3.95); and the 1-year mortality rate of 28-day survivors was 9.6% in diabetic men and 5.0% in nondiabetic men (HR, 1.97; 1.25-3.12) and 10.7% in diabetic women and 2.5% in nondiabetic women (HR, 4.17; 2.05-8.51). CONCLUSIONS: The high mortality rate of diabetic patients after their first myocardial infarction and the high proportion of out-of-hospital deaths in this group imply that vigorous primary and secondary preventive measures should become an integral part of their medical care.
OBJECTIVE: To study diabetic and nondiabetic patients with their first myocardial infarction to determine overall 1-year mortality, out-of-hospital mortality, 28-day mortality of hospitalized patients, and 1-year mortality of 28-day survivors. RESEARCH DESIGN AND METHODS: This study--based on the FINMONICA Myocardial Infarction Register, a part of the Finnish contribution to the WHO MONICA Project (World Health Organization Multinational Monitoring of Trends and Determinants of Cardiovascular Disease)--covered coronary heart disease (CHD) deaths and acute CHD events occurring during hospitalization among residents of Finland aged 25-64 years in three geographically defined areas. The study population comprised 620 diabetic and 3,445 nondiabetic patients who had their first myocardial infarction during the years 1988-1992. RESULTS: The age- and area-adjusted mortality rates and hazard ratios (HRs) for diabetic versus nondiabeticpatients (95% CI) were as follows: The 1-year mortality rate was 44.2% in diabeticmen and 32.6% in nondiabetic men (HR, 1.38; 1.18-1.61) and 36.9% in diabeticwomen and 20.2% in nondiabetic women (HR, 1.86; 1.40-2.46); the out-of-hospital mortality rate was 28.3% in diabeticmen and 22.4% in nondiabetic men (HR, 1.25; 1.03-1.52) and 10.4% in diabeticwomen and 11.0% in nondiabetic women (HR, 0.95; 0.58-1.54); the 28-day mortality rate of hospitalized patients was 14.4% in diabeticmen and 8.8% in nondiabetic men (HR, 1.58; 1.15-2.18) and 21.7% in diabeticwomen and 7.8% in nondiabetic women (HR, 2.60; 1.71-3.95); and the 1-year mortality rate of 28-day survivors was 9.6% in diabeticmen and 5.0% in nondiabetic men (HR, 1.97; 1.25-3.12) and 10.7% in diabeticwomen and 2.5% in nondiabetic women (HR, 4.17; 2.05-8.51). CONCLUSIONS: The high mortality rate of diabeticpatients after their first myocardial infarction and the high proportion of out-of-hospital deaths in this group imply that vigorous primary and secondary preventive measures should become an integral part of their medical care.
Authors: Whady Hueb; Neuza Lopes; Paulo R Soares; Bernard J Gersh; Eduardo Gomes Lima; Ricardo D Oliveira Vieira; Cibele Larrosa Garzillo; Rosa Rhami Garcia; Alexandre Costa Pereira; Celia Maria Strunz; Claudio Meneguetti; Jeane Tsutsui; Jose Parga; Pedro Lemos; Alexandre Hueb; Augusto Ushida; Raul Maranhão; Dalton A Chamone; Jose Af Ramires Journal: BMC Cardiovasc Disord Date: 2010-09-29 Impact factor: 2.298
Authors: Christof Prugger; Jan Heidrich; Jürgen Wellmann; Ralf Dittrich; Stefan-Martin Brand; Ralph Telgmann; Günter Breithardt; Holger Reinecke; Hans Scheld; Peter Kleine-Katthöfer; Peter U Heuschmann; Ulrich Keil Journal: Dtsch Arztebl Int Date: 2012-04-27 Impact factor: 5.594
Authors: Yanqiao Zhang; Florence Ying Lee; Gabriel Barrera; Hans Lee; Charisse Vales; Frank J Gonzalez; Timothy M Willson; Peter A Edwards Journal: Proc Natl Acad Sci U S A Date: 2006-01-12 Impact factor: 11.205
Authors: Birger Hesse; Christian Meyer; Flemming S Nielsen; Asako Sato; Jens D Hove; Soeren Holm; Lia E Bang; Klaus F Kofoed; Tage L Svendsen; Hans-Henrik Parving; Lionel H Opie Journal: Eur J Nucl Med Mol Imaging Date: 2003-12-05 Impact factor: 9.236