Literature DB >> 9538240

cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells.

T Ishino1, S Ohtsuki, K i Homma, S Natori.   

Abstract

A cDNA for mouse prolyl endopeptidase (PEP) was cloned and its nucleotide sequence determined. The overall amino acid sequence identity between mouse and other mammalian PEPs was about 96%. A specific inhibitor of PEP, N-benzyloxycarbonyl-thioprolyl-thioprolinal- dimethylacetal (ZTTA), inhibited DNA synthesis by Swiss 3T3 cells. Mouse PEP was shown to be localized partly in restricted nuclear regions. These results suggest that PEP participates in mammalian DNA synthesis.

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Year:  1998        PMID： 9538240     DOI： 10.1093/oxfordjournals.jbchem.a021970

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  10 in total

1.  Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen.

Authors:  Philip J O'Reilly; Matthew T Hardison; Patricia L Jackson; Xin Xu; Robert J Snelgrove; Amit Gaggar; F Shawn Galin; J Edwin Blalock
Journal:  J Neuroimmunol       Date:  2009-10-28       Impact factor: 3.478

2.  Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner.

Authors:  T T Myöhänen; J Tenorio-Laranga; B Jokinen; R Vázquez-Sánchez; M J Moreno-Baylach; J A García-Horsman; P T Männistö
Journal:  Br J Pharmacol       Date:  2011-08       Impact factor: 8.739

3.  Localization and subcellular distribution of prolyl oligopeptidase in the mouse placenta.

Authors:  Shin Matsubara; Takayuki Takahashi; Atsushi P Kimura
Journal:  J Mol Histol       Date:  2011-05-05       Impact factor: 2.611

4.  Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors.

Authors:  Timo T Myöhänen; Elisa Pyykkö; Pekka T Männistö; Olli Carpen
Journal:  J Histochem Cytochem       Date:  2012-06-26       Impact factor: 2.479

5.  Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues.

Authors:  Timo T Myöhänen; Jarkko I Venäläinen; J Arturo García-Horsman; Marjo Piltonen; Pekka T Männistö
Journal:  Histochem Cell Biol       Date:  2008-07-11       Impact factor: 4.304

Review 6.  Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity.

Authors:  Timo T Myöhänen; J Arturo García-Horsman; Jofre Tenorio-Laranga; Pekka T Männistö
Journal:  J Histochem Cytochem       Date:  2009-05-26       Impact factor: 2.479

7.  Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding.

Authors:  Swati Kaushik; Ramanathan Sowdhamini
Journal:  PLoS One       Date:  2011-11-23       Impact factor: 3.240

8.  OsPOP5, a prolyl oligopeptidase family gene from rice confers abiotic stress tolerance in Escherichia coli.

Authors:  Cun-Mei Tan; Rong-Jun Chen; Jian-Hua Zhang; Xiao-Ling Gao; Li-Hua Li; Ping-Rong Wang; Xiao-Jian Deng; Zheng-Jun Xu
Journal:  Int J Mol Sci       Date:  2013-10-10       Impact factor: 5.923

9.  Differential Distribution and Activity Profile of Acylpeptide Hydrolase in the Rat Seminiferous Epithelium.

Authors:  Alejandra A Covarrubias; Erwin De la Fuente-Ortega; Gabriela Rossi; Ennio Cocca; Mosè Rossi; Gianna Palmieri; Floria C Pancetti
Journal:  Biomedicines       Date:  2022-07-04

10.  Altered peptidase activities in thyroid neoplasia and hyperplasia.

Authors:  Gorka Larrinaga; Lorena Blanco; Peio Errarte; Maider Beitia; Begoña Sanz; Itxaro Perez; Amaia Irazusta; Clara E Sánchez; Francisco Santaolalla; Leire Andrés; José I López
Journal:  Dis Markers       Date:  2013-11-27       Impact factor: 3.434
  10 in total

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