Literature DB >> 9538133

Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas.

N Miyagi1, S Kato, M Terasaki, M Shigemori, M Morimatsu.   

Abstract

Fibroblast growth factor (FGF) signaling has been recognized in human gliomas. We tested the effect of FGF-2 and FGF-9 on the proliferation and the expression of matrix metalloproteinases (MMPs) and their inhibitor (TIMP-1) in vitro. Both FGFs showed mitogenic activity on U251MG and NMC-G1 cells. MMP-1 expression and collagenolytic activity of NMC-G1 but not of U251MG, and TIMP-1 expression of both cells were stimulated by FGFs. MMP-2 expression, gelatinolytic activity, and chemoinvasion on the matrigel were not altered. FGFs may regulate proliferation and microenvironmental factors independently in each glioma type.

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Year:  1998        PMID： 9538133     DOI： 10.3892/ijo.12.5.1085

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  6 in total

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2.  Medulloblastoma displays distinct regional matrix metalloprotease expression.

Authors:  G H Vince; C Herbold; R Klein; J Kühl; T Pietsch; S Franz; K Roosen; J C Tonn
Journal:  J Neurooncol       Date:  2001-06       Impact factor: 4.130

3.  Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades.

Authors:  S S Lakka; S L Jasti; A P Kyritsis; W K Yung; F Ali-Osman; G L Nicolson; J S Rao
Journal:  Clin Exp Metastasis       Date:  2000       Impact factor: 5.150

4.  Fibroblast growth factor-1 induced promatrilysin expression through the activation of extracellular-regulated kinases and STAT3.

Authors:  Thirupandiyur S Udayakumar; Mimi Suzanne Stratton; Raymond B Nagle; George Timothy Bowden
Journal:  Neoplasia       Date:  2002 Jan-Feb       Impact factor: 5.715

5.  Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in gliomas.

Authors:  Timothy E Van Meter; William C Broaddus; Harcharan K Rooprai; Geoffrey J Pilkington; Helen L Fillmore
Journal:  Neuro Oncol       Date:  2004-07       Impact factor: 12.300

6.  'Cut from the same cloth': Shared microsatellite variants among cancers link to ectodermal tissues-neural tube and crest cells.

Authors:  Enusha Karunasena; Lauren J Mciver; Jasmin H Bavarva; Xiaowei Wu; Hongxiao Zhu; Harold R Garner
Journal:  Oncotarget       Date:  2015-09-08
  6 in total

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