Literature DB >> 9537802

Ca2+ channel inhibition by endomorphins via the cloned mu-opioid receptor expressed in NG108-15 cells.

H Mima1, H Morikawa, K Fukuda, S Kato, T Shoda, K Mori.   

Abstract

Endomorphin-1 and -2, recently isolated endogenous peptides specific for the mu-opioid receptor, inhibited Ca2+ channel currents with EC50 of 6 and 9 nM, respectively, in NG108-15 cells transformed to express the cloned rat mu-opioid receptor. On the other hand, they elicited no response in nontransfected NG108-15 cells. It is concluded that endomorphin-1 and -2 induce Ca2+ channel inhibition by selectively activating the mu-opioid receptor.

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Year:  1997        PMID： 9537802

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum.

Authors:  L Romanelli; M C Amico; F Mattioli; L A Morrone; P Valeri
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

2.  Mu-opioid receptor modulation of calcium channel current in periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1.

Authors:  M Connor; A Schuller; J E Pintar; M J Christie
Journal:  Br J Pharmacol       Date:  1999-04       Impact factor: 8.739

3.  The effects of endomorphin-1 and endomorphin-2 in CHO cells expressing recombinant mu-opioid receptors and SH-SY5Y cells.

Authors:  C Harrison; S McNulty; D Smart; D J Rowbotham; D K Grandy; L A Devi; D G Lambert
Journal:  Br J Pharmacol       Date:  1999-09       Impact factor: 8.739

4.  Endomorphin 1 and endomorphin 2 suppress in vitro antibody formation at ultra-low concentrations: anti-peptide antibodies but not opioid antagonists block the activity.

Authors:  Benito Anton; Phillipe Leff; Juan C Calva; Rodolfo Acevedo; Alberto Salazar; Maura Matus; Lenin Pavón; Martin Martinez; Joseph J Meissler; Martin W Adler; John P Gaughan; Toby K Eisenstein
Journal:  Brain Behav Immun       Date:  2008-04-18       Impact factor: 7.217
  4 in total

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