Literature DB >> 9531422

Fmoc/Trt-amino acids: comparison to Fmoc/tBu-amino acids in peptide synthesis.

K Barlos1, D Gatos, S Koutsogianni.   

Abstract

Model peptides containing the nucleophilic amino acids Trp and Met have been synthesized with the application of Fmoc/Trt- and Fmoc/tBu-amino acids, for comparison. The deprotection of the peptides synthesized using Fmoc/Trt-amino acids in all cases leads to crude peptides of higher purity than that of the same peptides synthesized using Fmoc/tBu-amino acids.

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Year:  1998        PMID: 9531422     DOI: 10.1111/j.1399-3011.1998.tb01216.x

Source DB:  PubMed          Journal:  J Pept Res        ISSN: 1397-002X


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