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Literature DB >> 9529611

The patched gene in development and cancer.

Abstract

The cloning of vertebrate homologues of the Drosophila segment polarity gene patched has led to confirmation of a role for the multipass transmembrane protein which it encodes as a receptor for secreted signalling proteins of the Hedgehog family. In addition, human patched has been identified as a tumour suppressor gene implicated in basal cell carcinomas and medullablastomas.

Entities: Disease Gene Species

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Year: 1998 PMID： 9529611 DOI： 10.1016/s0959-437x(98)80067-1

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

14 in total

1. Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene.

Authors: Rondell P Graham; Asha A Nair; Jaime I Davila; Long Jin; Jin Jen; William R Sukov; Tsung-Teh Wu; Henry D Appelman; Jorge Torres-Mora; Kyle D Perry; Lizhi Zhang; Sara M Kloft-Nelson; Ryan A Knudson; Patricia T Greipp; Andrew L Folpe
Journal: Mod Pathol Date: 2017-07-21 Impact factor: 7.842

Review 2. Hedgehog signaling in mouse mammary gland development and neoplasia.

Authors: M T Lewis
Journal: J Mammary Gland Biol Neoplasia Date: 2001-01 Impact factor: 2.673

3. A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis.

Authors: P E Kuwabara; M H Lee; T Schedl; G S Jefferis
Journal: Genes Dev Date: 2000-08-01 Impact factor: 11.361

Review 4. Cilia in the CNS: the quiet organelle claims center stage.

Authors: Angeliki Louvi; Elizabeth A Grove
Journal: Neuron Date: 2011-03-24 Impact factor: 17.173

5. The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling.

Authors: Manuel Ascano; Kent E Nybakken; Janek Sosinski; Melanie A Stegman; David J Robbins
Journal: Mol Cell Biol Date: 2002-03 Impact factor: 4.272

6. Subgroup-specific alternative splicing in medulloblastoma.

Authors: Adrian M Dubuc; A Sorana Morrissy; Nanne K Kloosterhof; Paul A Northcott; Emily Py Yu; David Shih; John Peacock; Wieslawa Grajkowska; Timothy van Meter; Charles G Eberhart; Stefan Pfister; Marco A Marra; William A Weiss; Stephen W Scherer; James T Rutka; Pim J French; Michael D Taylor
Journal: Acta Neuropathol Date: 2012-02-23 Impact factor: 17.088

The patched gene in development and cancer.

1. Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene.

Review 2. Hedgehog signaling in mouse mammary gland development and neoplasia.

3. A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis.

Review 4. Cilia in the CNS: the quiet organelle claims center stage.

5. The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling.

6. Subgroup-specific alternative splicing in medulloblastoma.

7. Patched regulation of axon guidance is by specifying neural identity in the Drosophila nerve cord.

Review 8. Enhancement of anti-tumor immunity by photodynamic therapy.

9. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.

10. Enhanced systemic immune reactivity to a Basal cell carcinoma associated antigen following photodynamic therapy.