Literature DB >> 9529600

Functions of the BRCA1 and BRCA2 genes.

D Bertwistle1, A Ashworth.   

Abstract

Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cellular function of these genes but also how their loss leads to tumour formation.

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Year:  1998        PMID： 9529600     DOI： 10.1016/s0959-437x(98)80056-7

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  17 in total

1.  Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations.

Authors:  B H Spain; C J Larson; L S Shihabuddin; F H Gage; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-23       Impact factor: 11.205

2.  CBP/p300 interact with and function as transcriptional coactivators of BRCA1.

Authors:  G M Pao; R Janknecht; H Ruffner; T Hunter; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

Review 3.  Fine tuning chemotherapy to match BRCA1 status.

Authors:  Melissa Price; Alvaro N A Monteiro
Journal:  Biochem Pharmacol       Date:  2010-05-25       Impact factor: 5.858

4.  Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.

Authors:  X Zhang; S Moréra; P A Bates; P C Whitehead; A I Coffer; K Hainbucher; R A Nash; M J Sternberg; T Lindahl; P S Freemont
Journal:  EMBO J       Date:  1998-11-02       Impact factor: 11.598

5.  Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

Authors:  R S Tibbetts; D Cortez; K M Brumbaugh; R Scully; D Livingston; S J Elledge; R T Abraham
Journal:  Genes Dev       Date:  2000-12-01       Impact factor: 11.361

Review 6.  Developmental studies of Brca1 and Brca2 knock-out mice.

Authors:  R Hakem; J L de la Pompa; T W Mak
Journal:  J Mammary Gland Biol Neoplasia       Date:  1998-10       Impact factor: 2.673

7.  Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.

Authors:  A Tutt; D Bertwistle; J Valentine; A Gabriel; S Swift; G Ross; C Griffin; J Thacker; A Ashworth
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

8.  Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.

Authors:  N J Marston; W J Richards; D Hughes; D Bertwistle; C J Marshall; A Ashworth
Journal:  Mol Cell Biol       Date:  1999-07       Impact factor: 4.272

Review 9.  The PI3K-PDK1 connection: more than just a road to PKB.

Authors:  B Vanhaesebroeck; D R Alessi
Journal:  Biochem J       Date:  2000-03-15       Impact factor: 3.857

10.  BRCA1 polymorphisms and breast cancer epidemiology in the Western New York exposures and breast cancer (WEB) study.

Authors:  Luisel J Ricks-Santi; Jing Nie; Catalin Marian; Heather M Ochs-Balcom; Maurizio Trevisan; Stephen B Edge; Yasmine Kanaan; Jo L Freudenheim; Peter G Shields
Journal:  Genet Epidemiol       Date:  2013-05-14       Impact factor: 2.135
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