UNLABELLED: This study was undertaken to assess the relationship between the degree of 99mTc-MIBI uptake in breast lesions and the following histologic factors: neovascularity, desmoplastic reaction, cellular proliferation and mitochondrial density. METHODS: Forty-two patients who previously underwent MIBI breast imaging (4 false-negative, 12 false-positive, 15 true-negative, 11 true-positive) were studied. Immunohistochemical staining was performed for neovascularity (Factor VIII antigen), desmoplasia (alpha-actin antigen), mitochondrial density (mitochondrial antigen) and cellular proliferation (MIB-1 antigen). The degree of microscopic staining was correlated with region of interest measurements of MIBI uptake on scintigraphy. RESULTS: There was a poor correlation between MIBI uptake and the degrees of neovascularity (r = 0.08, p > 0.05) and intracellular mitochondrial density (r = 0.04, p > 0.05) while there was a moderate correlation with cellular proliferation (r = 0.4, p < 0.05) and desmoplasia (r = 0.55, p < 0.001). CONCLUSION: The degree of MIBI uptake in breast lesions is multifactorial, but it appears to be related more to the degree of desmoplastic activity and cellular proliferation than neovascularity and mitochondrial density.
UNLABELLED: This study was undertaken to assess the relationship between the degree of 99mTc-MIBI uptake in breast lesions and the following histologic factors: neovascularity, desmoplastic reaction, cellular proliferation and mitochondrial density. METHODS: Forty-two patients who previously underwent MIBI breast imaging (4 false-negative, 12 false-positive, 15 true-negative, 11 true-positive) were studied. Immunohistochemical staining was performed for neovascularity (Factor VIII antigen), desmoplasia (alpha-actin antigen), mitochondrial density (mitochondrial antigen) and cellular proliferation (MIB-1 antigen). The degree of microscopic staining was correlated with region of interest measurements of MIBI uptake on scintigraphy. RESULTS: There was a poor correlation between MIBI uptake and the degrees of neovascularity (r = 0.08, p > 0.05) and intracellular mitochondrial density (r = 0.04, p > 0.05) while there was a moderate correlation with cellular proliferation (r = 0.4, p < 0.05) and desmoplasia (r = 0.55, p < 0.001). CONCLUSION: The degree of MIBI uptake in breast lesions is multifactorial, but it appears to be related more to the degree of desmoplastic activity and cellular proliferation than neovascularity and mitochondrial density.
Authors: Antonio Piñero; Pedro José Galindo; Julián Illana; Francisco Nicolás; Manuel Reus; María Dolores Hernández; Isidro Durán; Manuel Canteras; Pascual Parrilla Journal: Clin Transl Oncol Date: 2006-02 Impact factor: 3.405
Authors: Vassilios J Papantoniou; Michael A Souvatzoglou; Varvara J Valotassiou; Androniki N Louvrou; Constantina Ambela; John Koutsikos; Dimitrios Lazaris; Julie K Christodoulidou; Maria G Sotiropoulou; Maria J Melissinou; Aris Perperoglou; Spyridon Tsiouris; Cherry J Zerva Journal: Breast Cancer Res Date: 2003-12-11 Impact factor: 6.466
Authors: Vassilios Papantoniou; Spyridon Tsiouris; Ekaterini Mainta; Varvara Valotassiou; Michael Souvatzoglou; Maria Sotiropoulou; Lydia Nakopoulou; Dimitrios Lazaris; Androniki Louvrou; Maria Melissinou; Artemis Tzannetaki; Ioannis Pirmettis; John Koutsikos; Cherry Zerva Journal: Breast Cancer Res Date: 2004-11-08 Impact factor: 6.466