Literature DB >> 952929

Branched-chain amino acid oxidation by isolated rat tissue preparations.

F L Shinnick, A E Harper.   

Abstract

Branched-chain amino acid transaminase activity, branced-chain alpha-keto acid dehydrogenase activity, and leucine oxidation were measured in homogenates and slices of several rat tissues. Transaminase activity was highest in heart, while dehydrogenase activity was highest in liver. Leucine oxidation in isolated tissues may be limited by either transaminase or dehydrogenase activity depending upon the relative activities of these two enzymes in the tissue. The results suggest that, as the load of branched-chain amino acids increases, the liver may become an increasingly important site for the degradation of branched-chain alpha-keto acids.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 952929     DOI： 10.1016/0304-4165(76)90016-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  37 in total

1.  Cell swelling inhibits proteolysis in perfused rat liver.

Authors:  D Häussinger; C Hallbrucker; S vom Dahl; F Lang; W Gerok
Journal:  Biochem J       Date:  1990-11-15       Impact factor: 3.857

Review 2.  Amino acid metabolism during exercise and following endurance training.

Authors:  D A Hood; R L Terjung
Journal:  Sports Med       Date:  1990-01       Impact factor: 11.136

3.  Human branched-chain L-amino acid aminotransferase: Activity and subcellular localization in cultured skin fibroblasts.

Authors:  P Schadewaldt; U Wendel; H W Hammen
Journal:  Amino Acids       Date:  1995-06       Impact factor: 3.520

4.  Liver autophagy contributes to the maintenance of blood glucose and amino acid levels.

Authors:  Junji Ezaki; Naomi Matsumoto; Mitsue Takeda-Ezaki; Masaaki Komatsu; Katsuyuki Takahashi; Yuka Hiraoka; Hikari Taka; Tsutomu Fujimura; Kenji Takehana; Mitsutaka Yoshida; Junichi Iwata; Isei Tanida; Norihiko Furuya; Dong-Mei Zheng; Norihiro Tada; Keiji Tanaka; Eiki Kominami; Takashi Ueno
Journal:  Autophagy       Date:  2011-07-01       Impact factor: 16.016

5.  Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury.

Authors:  James P Fabisiak; Mario Medvedovic; Danny C Alexander; Jonathan E McDunn; Vincent J Concel; Kiflai Bein; An Soo Jang; Annerose Berndt; Louis J Vuga; Kelly A Brant; Hannah Pope-Varsalona; Richard A Dopico; Koustav Ganguly; Swapna Upadhyay; Qian Li; Zhen Hu; Naftali Kaminski; George D Leikauf
Journal:  Mol Nutr Food Res       Date:  2011-08-08       Impact factor: 5.914

6.  The effects of high intensity exercise on muscle and plasma levels of alpha-ketoisocaproic acid.

Authors:  R A Fielding; W J Evans; V A Hughes; L L Moldawer; B R Bistrian
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1986

7.  Lipopolysaccharide (LPS) increases the in vivo oxidation of branched-chain amino acids in the rat: a cytokine-mediated effect.

Authors:  C García-Martínez; M Llovera; F J López-Soriano; B del Santo; J M Argilés
Journal:  Mol Cell Biochem       Date:  1995-07-05       Impact factor: 3.396

8.  The activity state of the branched-chain 2-oxo acid dehydrogenase complex in rat tissues.

Authors:  A J Wagenmakers; J T Schepens; J A Veldhuizen; J H Veerkamp
Journal:  Biochem J       Date:  1984-05-15       Impact factor: 3.857

9.  Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.

Authors:  Shih-Chia Tso; Xiangbing Qi; Wen-Jun Gui; Jacinta L Chuang; Lorraine K Morlock; Amy L Wallace; Kamran Ahmed; Sunil Laxman; Philippe M Campeau; Brendan H Lee; Susan M Hutson; Benjamin P Tu; Noelle S Williams; Uttam K Tambar; R Max Wynn; David T Chuang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-28       Impact factor: 11.205

10.  Kidney, splanchnic, and leg protein turnover in humans. Insight from leucine and phenylalanine kinetics.

Authors:  P Tessari; G Garibotto; S Inchiostro; C Robaudo; S Saffioti; M Vettore; M Zanetti; R Russo; G Deferrari
Journal:  J Clin Invest       Date:  1996-09-15       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.