| Literature DB >> 9529155 |
K Takeda1, H Tsutsui, T Yoshimoto, O Adachi, N Yoshida, T Kishimoto, H Okamura, K Nakanishi, S Akira.
Abstract
IL-18 is a cytokine that is secreted from activated macrophages and induces IFNgamma production. To investigate the in vivo role of IL-18, we generated IL-18-deficient mice. In Propionibacterium acnes (P. acnes)-primed IL-18-deficient mice, LPS-induced IFNgamma production was markedly reduced, despite normal IL-12 induction. Natural killer cell activity was significantly impaired. Th1 cell response after injection of P. acnes or Mycobacterium bovis (bacillus Calmette-Guerin [BCG]) was significantly reduced. Similar results were observed in IL-12-deficient mice. Interestingly, Th1 response was induced after BCG infection in IL-12-deficient mice. We therefore generated mice lacking both IL-18 and IL-12. In these mice, NK activity and Th1 response were further impaired. This demonstrates the important role of both IL-18 and IL-12 in NK activity, as well as in in vivo Th1 response.Entities:
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Year: 1998 PMID： 9529155 DOI： 10.1016/s1074-7613(00)80543-9
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745