Literature DB >> 9529109

Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli.

G Ben-Ami1, V Ozeri, E Hanski, F Hofmann, K Aktories, K M Hahn, G M Bokoch, I Rosenshine.   

Abstract

Enteropathogenic Escherichia coli (EPEC) induces formation of actin pedestals in infected host cells. Agents that inhibit the activity of Rho, Rac, and Cdc42, including Clostridium difficile toxin B (ToxB), compactin, and dominant negative Rho, Rac, and Cdc42, did not inhibit formation of actin pedestals. In contrast, treatment of HeLa cells with ToxB inhibited EPEC invasion. Thus, Rho, Rac, and Cdc42 are not required for assembly of actin pedestals; however, they may be involved in EPEC uptake by HeLa cells.

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Year:  1998        PMID： 9529109      PMCID： PMC108116     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  10 in total

1.  Construction and analysis of TnphoA mutants of enteropathogenic Escherichia coli unable to invade HEp-2 cells.

Authors:  M S Donnenberg; S B Calderwood; A Donohue-Rolfe; G T Keusch; J B Kaper
Journal:  Infect Immun       Date:  1990-06       Impact factor: 3.441

2.  A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation.

Authors:  I Rosenshine; S Ruschkowski; M Stein; D J Reinscheid; S D Mills; B B Finlay
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

3.  Novel form of actin-based motility transports bacteria on the surfaces of infected cells.

Authors:  J M Sanger; R Chang; F Ashton; J B Kaper; J W Sanger
Journal:  Cell Motil Cytoskeleton       Date:  1996

Review 4.  Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton.

Authors:  N Tapon; A Hall
Journal:  Curr Opin Cell Biol       Date:  1997-02       Impact factor: 8.382

5.  Attaching and effacing of host cells by enteropathogenic Escherichia coli in the absence of detectable tyrosine kinase mediated signal transduction.

Authors:  R P Rabinowitz; L C Lai; K Jarvis; T K McDaniel; J B Kaper; K D Stone; M S Donnenberg
Journal:  Microb Pathog       Date:  1996-09       Impact factor: 3.738

6.  Glucosylation of Rho proteins by Clostridium difficile toxin B.

Authors:  I Just; J Selzer; M Wilm; C von Eichel-Streiber; M Mann; K Aktories
Journal:  Nature       Date:  1995-06-08       Impact factor: 49.962

7.  Improved green fluorescence.

Authors:  R Heim; A B Cubitt; R Y Tsien
Journal:  Nature       Date:  1995-02-23       Impact factor: 49.962

8.  A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells.

Authors:  A E Jerse; J Yu; B D Tall; J B Kaper
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

9.  The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells.

Authors:  L D Chong; A Traynor-Kaplan; G M Bokoch; M A Schwartz
Journal:  Cell       Date:  1994-11-04       Impact factor: 41.582

10.  Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake.

Authors:  I Rosenshine; M S Donnenberg; J B Kaper; B B Finlay
Journal:  EMBO J       Date:  1992-10       Impact factor: 11.598
  10 in total
  20 in total

1.  Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals.

Authors:  D Kalman; O D Weiner; D L Goosney; J W Sedat; B B Finlay; A Abo; J M Bishop
Journal:  Nat Cell Biol       Date:  1999-10       Impact factor: 28.824

2.  Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.

Authors:  Takeshi Matsuzawa; Asaomi Kuwae; Sei Yoshida; Chihiro Sasakawa; Akio Abe
Journal:  EMBO J       Date:  2004-08-19       Impact factor: 11.598

3.  Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulin.

Authors:  Matthew D Brown; Lynn Bry; Zhigang Li; David B Sacks
Journal:  J Biol Chem       Date:  2008-09-22       Impact factor: 5.157

4.  Transient shielding of intimin and the type III secretion system of enterohemorrhagic and enteropathogenic Escherichia coli by a group 4 capsule.

Authors:  Yulia Shifrin; Adi Peleg; Ophir Ilan; Chen Nadler; Simi Kobi; Kobi Baruch; Gal Yerushalmi; Tatiana Berdichevsky; Shoshy Altuvia; Maya Elgrably-Weiss; Cecilia Abe; Stuart Knutton; Chihiro Sasakawa; Jennifer M Ritchie; Matthew K Waldor; Ilan Rosenshine
Journal:  J Bacteriol       Date:  2008-05-23       Impact factor: 3.490

5.  EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability.

Authors:  Janneth Peralta-Ramírez; J Manuel Hernandez; Rebeca Manning-Cela; José Luna-Muñoz; Carlos Garcia-Tovar; Jean-Philippe Nougayréde; Eric Oswald; Fernando Navarro-Garcia
Journal:  Infect Immun       Date:  2008-06-16       Impact factor: 3.441

6.  Structural and functional studies indicate that the EPEC effector, EspG, directly binds p21-activated kinase.

Authors:  Katherine L Germane; Benjamin W Spiller
Journal:  Biochemistry       Date:  2011-01-24       Impact factor: 3.162

7.  Recruitment of cytoskeletal and signaling proteins to enteropathogenic and enterohemorrhagic Escherichia coli pedestals.

Authors:  D L Goosney; R DeVinney; B B Finlay
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

8.  Dominant-negative Rho, Rac, and Cdc42 facilitate the invasion process of Vibrio parahaemolyticus into Caco-2 cells.

Authors:  Yukihiro Akeda; Toshio Kodama; Takashige Kashimoto; Vlademir Cantarelli; Yasuhiko Horiguchi; Kenichi Nagayama; Tetsuya Iida; Takeshi Honda
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

9.  Enteropathogenic Escherichia coli activates ezrin, which participates in disruption of tight junction barrier function.

Authors:  I Simonovic; M Arpin; A Koutsouris; H J Falk-Krzesinski; G Hecht
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

10.  Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.

Authors:  John J Garber; Fuminao Takeshima; Inés M Antón; Michiko K Oyoshi; Anna Lyubimova; Archana Kapoor; Tomoyuki Shibata; Feng Chen; Frederick W Alt; Raif S Geha; John M Leong; Scott B Snapper
Journal:  Infect Immun       Date:  2012-09-10       Impact factor: 3.441
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